Table 3 Diagnostic indices of maternal PlGF, sFLT-1, and their ratio for identifying patients who will develop preeclampsia, hypertension without proteinuria, normotensive IUGR, and induced delivery at <34 weeks of gestation
Chi-Square P-value | Sensitivity | Specificity | PPV | NPV | LR + (95% CI) | LR- (95% CI) | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
PE (n = 12) | PlGF | 0.027 | 58.3% | 78.9% | 46.7% | 85.7% | 2.77 (1.27-6.04) | 0.53 (0.27-1.05) | 5.25 (1.31-21.03) |
sFLT-1 | 0.240 | 16.7% | 94.7% | 50.0% | 78.3% | 3.17 (0.50-20.13) | 0.88 (0.68-1.15) | 3.60 (0.45-28.86) | |
sFLT-1/PlGF ratio | <0.001 | 66.7% | 89.5% | 66.7% | 89.5% | 6.33 (2.31-17.38) | 0.37 (0.17-0.84) | 17.0 (3.50-83.02) | |
Gestational hypertension (n = 16) | PlGF | 0.514 | 37.5% | 73.5% | 40.0% | 71.4% | 1.42 (0.61-3.30) | 0.85 (0.55-1.31) | 1.67 (0.47-5.92) |
sFLT-1 | 1.000 | 6.3% | 91.2% | 25.0% | 67.4% | 0.71 (0.08-6.29) | 1.03 (0.87-1.21) | 0.69 (0.067-7.19) | |
sFLT-1/PlGF ratio | 0.292 | 12.5% | 70.6% | 16.7% | 63.2% | 0.43 (0.11-1.72) | 1.24 (0.93-1.65) | 0.34 (0.07-1.79) | |
IUGR (n = 6) | PlGF | 0.654 | 16.7% | 68.2% | 6.7% | 85.7% | 0.52 (0.08-3.30) | 1.22 (0.81-1.84) | 0.43 (0.05-4.02) |
sFLT-1 | 1.000 | 0.0% | 90.9% | 0.0% | 87.0% | 0.00 | 1.10 (1.00-1.21) | 0.00 | |
sFLT-1/PlGF ratio | 1.000 | 16.7% | 75.0% | 8.3% | 86.8% | 0.67 (0.10-4.29) | 1.11 (0.75-1.65) | 0.60 (0.06-5.71) | |
Induced delivery < 34 weeks (n = 7) | PlGF | 0.176 | 57.1% | 74.4% | 26.7% | 91.4% | 2.23 (0.98-5.07) | 0.58 (0.34-1.38) | 3.88 (0.75-20.12) |
sFLT-1 | 0.089 | 28.6% | 95.4% | 50.3% | 89.1% | 6.14 (1.03-36.79) | 0.75 (0.47-1.20) | 8.20 (0.94-71.73) | |
sFLT-1/PlGF ratio | <0.001 | 85.7% | 86.1% | 50.1% | 97.4% | 6.14 (2.76-13.69) | 0.17 (0.03-1.02) | 37.00 (3.76-363.91) | |
Early-onset PE (n = 9) | PlGF | 0.220 | 50.0% | 73.8% | 26.7% | 88.6% | 1.91 (0.81-4.51) | 0.68 (0.33-1.39) | 2.82 (0.60-13.24) |
sFLT-1 | 0.115 | 25.0% | 95.2% | 50.0% | 87.0% | 5.25 (0.86-32.02) | 0.79 (0.53-1.18) | 6.67 (0.79-56.64) | |
sFLT-1/PlGF ratio | 0.001 | 75.0% | 85.7% | 50.0% | 94.7% | 5.25 (2.26-12.18) | 0.29 (0.09-0.98) | 18.00 (2.92-110.96) | |
Late-onset PE (n = 3) | PlGF | 0.075 | 75.0% | 73.9% | 20.0% | 97.1% | 2.88 (1.36-6.06) | 0.34 (0.06-1.86) | 8.50 (0.81-89.75) |
sFLT-1 | 1.000 | 0.0% | 91.3% | 0.0% | 91.3% | 0.00 | 1.10 (1.00-1.20) | 0.00 | |
sFLT-1/PlGF ratio | 0.240 | 50.0% | 78.3% | 16.7% | 94.7% | 2.30 (0.75-7.07) | 0.64 (0.24-1.72) | 3.60 (0.46-28.86) |