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Table 3 Summary of study results for women with known membrane status; women included in studies who had a confirmed membrane rupture or intact membranes (not suspected of PROM) upon entry to the study

From: Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Study

N

TP

FN

TN

FP

Sensitivity% (CI)

Specificity% (CI)

PPV% (CI)

NPV% (CI)

Marcellin 2011 [60]

79

39

1

38

1

97.5 (85.7–100)

97.4 (82.4–99.4)

97.5 (88.5–100)

97.4 (92.5–100)

Martinez de Tejada 2006 [52]

34

20

0

13

1

100 (79.9–100)

92.8 (64.2–99.6)

95.2 (74.1–99.7)

100 (71.7–100)

Akercan 2005 [54]

45

25

0

19

1

100 (83.4–100)

95.0 (73.1–99.7)

96.1 (78.4–99.8)

100 (79.1–100)

Erdermoglu 2004 [47]

71

35

1

34

1

97.2 (83.8–99.8)

97.1 (83.4–99.8)

97.2 (83.8–99.8)

97.1 (83.4–99,8)

Darj 1998 [51]

75

44

2

27

2

95.6 (84.0–99.2)

93.1 (75.8–98.8)

95.7 (84.0–99.2)

93.1 (75.8–98.8)

Gaucherand 1997 [53]

69

34

1

34

0

97.1 (83.4–99.8)

100 (87.4–99.8)

100 (87.4–100)

97.1 (83.4–99.8)

Guibourdenche 1999 [48]

30

15

0

14

1

100 (74.6–100)

93.3 (66.0–99.7)

93.8 (67.7–99.7)

100 (73.2–100)

Rutanen 1996 [12]

130

55

0

71

4

100 (91.9–100)

94.7 (86.2–98.3)

93.2 (82.7–97.8)

100 (93.6–100)

Actim PROM® pooled

533

267

5

250

11

98.2 (95.5–99.3)

95.8 (92.4–97.8)

96.0 (92.8–97.9)

98.0 (95.2–99.3)

Abdelazim 2012 [58]

150

73

2

74

1

97.3 (89.8–99.5)

98.7 (91.8–99.9)

98.6 (91.7–99.9)

97.4 (90.0–99.5)

Marcellin 2011 [60]

79

38

2

38

1

95.0 (82.4–99.4)

94.8 (79.3–98.0)

95.0 (84.7–100)

94.8 (87.9–100)

AmniSure® pooled

229

111

4

112

2

96.5 (90.8–98.9)

98.2 (93.2–99.7)

98.2 (93.1–99.7)

96.5 (90.9–98.9)

  1. CI: Confidence Interval; TP: True Positives; FN: False Negatives; TN: True Negatives; FP: False Positives.