Meta-analysis of studies on biochemical marker tests for the diagnosis of premature rupture of membranes: comparison of performance indexes

Table 1 Biomarker and rapid test characteristics

	Biomarker	Biomarker concentrations in bodily fluids		Rapid test characteristics
	Biomarker	Maternal blood	Amniotic fluid	Threshold	Time to obtain results
Actim® PROM	IGFBP-1	29–300 μg/L [12, 14]	10,500–350,000 μg/L [12, 14]	>25 μg/L [12, 14]	<5 minutes, if positive At 5 minutes, if negative
AmniSure®	PAMG-1	2.5–12.5 ng/ml*	2,000–25,000 ng/ml*	>5 ng/ml*	10 minutes after sampling False results after 15 minutes

*Unpublished values stated in the AmniSure® manufacturer’s instructions for use and information material

ISSN: 1471-2393