False positive morphologic diagnoses at the anomaly scan: marginal or real problem, a population-based cohort study

Table 5 Rates of false positives and diagnostic misclassifications by anatomical system (number of files)

Malformations identified in utero	False positives	Misclassification	p⁴
Malformations identified in utero	% (95% CI)	% (95% CI)
Bone malformations (n = 56)	3.6 (0.04-12.3)	12.5 (5.2-24.1)	0.10
Cardiac malformations¹ (n = 86)	3.4 (0.07-9.5)	14.6 (8.0-23.7)	0.01
Cerebral malformations² (n = 98)	7.1 (4.2-16.4)	15.3 (8.7-23.5)	0.22
Malformations of the respiratory system and intrathoracic organs (n = 16)	6.3 (1.5-36.4)	0	0.16
Craniofacial malformations (n = 45)	4.4 (5.4-15.1)	15.6 (6.5-29.5)	0.09
Malformations of the eyes (n = 4)	0	25 (0-67.4)	0.31
Malformations anterior abdominal wall (n = 14)	7.1 (0-20.6)	21.4 (4.6-50.8)	0.32
Malformations of genital organs (n = 35)	5.7 (2.4-28.1)	7.9 (1.7-21.4)	0.48
Renal malformations ³(n = 169)	11.8 (7.4-17.7)	13.6 (8.8-19.7)	0.65
Malformations of the gastrointestinal tract (n = 41)	12.2 (4.1-26.2)	9.8 (2.7-23.1)	0.73

¹The specific cardiac anomaly most often misdiagnosed was ventricular septal defect (n = 5).
²The specific cerebral anomalies most often misdiagnosed were anomaly of the corpus callosum (n = 5) and ventriculomegaly (n = 5).
³The specific renal anomaly most overdiagnosed in the false-positive group was renal pyelectasis (n = 15).
⁴Comparison between 2 groups: False positives, Misclassification.

ISSN: 1471-2393