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Table 5 Rates of false positives and diagnostic misclassifications by anatomical system (number of files)

From: False positive morphologic diagnoses at the anomaly scan: marginal or real problem, a population-based cohort study

Malformations identified in utero False positives Misclassification p4
% (95% CI) % (95% CI)  
Bone malformations (n = 56) 3.6 (0.04-12.3) 12.5 (5.2-24.1) 0.10
Cardiac malformations1 (n = 86) 3.4 (0.07-9.5) 14.6 (8.0-23.7) 0.01
Cerebral malformations2 (n = 98) 7.1 (4.2-16.4) 15.3 (8.7-23.5) 0.22
Malformations of the respiratory system and intrathoracic organs (n = 16) 6.3 (1.5-36.4) 0 0.16
Craniofacial malformations (n = 45) 4.4 (5.4-15.1) 15.6 (6.5-29.5) 0.09
Malformations of the eyes (n = 4) 0 25 (0-67.4) 0.31
Malformations anterior abdominal wall (n = 14) 7.1 (0-20.6) 21.4 (4.6-50.8) 0.32
Malformations of genital organs (n = 35) 5.7 (2.4-28.1) 7.9 (1.7-21.4) 0.48
Renal malformations 3(n = 169) 11.8 (7.4-17.7) 13.6 (8.8-19.7) 0.65
Malformations of the gastrointestinal tract (n = 41) 12.2 (4.1-26.2) 9.8 (2.7-23.1) 0.73
  1. 1The specific cardiac anomaly most often misdiagnosed was ventricular septal defect (n = 5).
  2. 2The specific cerebral anomalies most often misdiagnosed were anomaly of the corpus callosum (n = 5) and ventriculomegaly (n = 5).
  3. 3The specific renal anomaly most overdiagnosed in the false-positive group was renal pyelectasis (n = 15).
  4. 4Comparison between 2 groups: False positives, Misclassification.