Table 3 Serial angiogenic markers in pregnancy and pregnancy outcome
Time point of measurement (EGA) | Angiogenic marker | Preeclamptic pregnancies (n = 19) | Normal pregnancies (n = 408) | p-value |
|---|---|---|---|---|
|  | sFlt-1 | 4.1 (2.3–5.5) | 5.4 (3.5–7.5) | 0.03 |
8–10 weeks | PlGF | 24.1 (15.2–43.0) | 20.7 (15.0–29.5 | 0.5 |
|  | sFlt-1/PlGF ratio | 155.3 (85.5–195.7) | 235.3 (147.2–343.5) | 0.002 |
|  | sFlt-1 | 5.7 (3.2–9.2) | 6.3 (3.9–9.0) | 0.6 |
17–19 weeks | PlGF | 112.8 (81.7–175.6) | 136.4 (100.5–192.7) | 0.3 |
|  | sFlt-1/PlGF ratio | 35.8 (26.4–66.9) | 47.1 (28.2–74.7) | 0.6 |
|  | sFlt-1 | 6.3 (3.0–9.7) | 5.7 (3.9–8.9) | 0.8 |
23–25 weeks | PlGF | 354.2 (182.6–583.1) | 451.3 (303.9–651.0) | 0.07 |
|  | sFlt-1/PlGF ratio | 13.9 (8.5–32.2) | 12.6 (7.9–21.5) | 0.2 |
|  | sFlt-1 | 16.7 (9.0–26.7) | 9.2 (6.4–13.7) | 0.002 |
34–35 weeks | PlGF | 247.9 (102.2–589.9) | 372.4 (186.1–707.1) | 0.09 |
|  | sFlt-1/PlGF ratio | 74.0 (14.7–261.6) | 25.3 (10.3–64.2) | 0.03 |