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Table 3 Serial angiogenic markers in pregnancy and pregnancy outcome

From: First trimester PAPP-A levels correlate with sFlt-1 levels longitudinally in pregnant women with and without preeclampsia

Time point of measurement (EGA) Angiogenic marker Preeclamptic pregnancies (n = 19) Normal pregnancies (n = 408) p-value
  sFlt-1 4.1 (2.3–5.5) 5.4 (3.5–7.5) 0.03
8–10 weeks PlGF 24.1 (15.2–43.0) 20.7 (15.0–29.5 0.5
  sFlt-1/PlGF ratio 155.3 (85.5–195.7) 235.3 (147.2–343.5) 0.002
  sFlt-1 5.7 (3.2–9.2) 6.3 (3.9–9.0) 0.6
17–19 weeks PlGF 112.8 (81.7–175.6) 136.4 (100.5–192.7) 0.3
  sFlt-1/PlGF ratio 35.8 (26.4–66.9) 47.1 (28.2–74.7) 0.6
  sFlt-1 6.3 (3.0–9.7) 5.7 (3.9–8.9) 0.8
23–25 weeks PlGF 354.2 (182.6–583.1) 451.3 (303.9–651.0) 0.07
  sFlt-1/PlGF ratio 13.9 (8.5–32.2) 12.6 (7.9–21.5) 0.2
  sFlt-1 16.7 (9.0–26.7) 9.2 (6.4–13.7) 0.002
34–35 weeks PlGF 247.9 (102.2–589.9) 372.4 (186.1–707.1) 0.09
  sFlt-1/PlGF ratio 74.0 (14.7–261.6) 25.3 (10.3–64.2) 0.03
  1. Data presented as median (interquartile range).
  2. sFlt-1 in ng/mL; PlGF in pg/mL; for calculation of sFlt-1/PlGF ratio, sFlt-1 was first converted to pg/mL.