Variation in endoglin pathway genes is associated with preeclampsia: a case–control candidate gene association study

Table 2 White subgroup demographic and clinical characteristics

Variable	Cases (n = 181)	Controls (n = 174)	p-value
Maternal age, years (M (SD))	28.3 (5.8)	28.4 (5.7)	0.87^a
Gravida (Mdn (min-max))	1 (1-6)	1 (1-8)	0.08^b
Nulliparous (n, %)	146 (80.7%)	139 (79.9%)	0.85^c
Gestational age at delivery, wks (M (SD))	36.1 (3.2)	39.6 (1.1)	< 0 .001 ^d
Birthweight, grams (M (SD)) ^e	2497.5 (841.2)	3481.6 (446.3)	< 0.001 ^d
Avg. SBP < 20 weeks’, mm Hg (M (SD)) ^f	116.6 (9.6)	112.1 (7.5)	< 0.001 ^d
Avg. DBP < 20 weeks’, mm Hg (M (SD)) ^f	71.7 (7.2)	68.1 (4.9)	< 0.001 ^d
Avg. SBP in labor, mm Hg (M (SD)) ^g	154.8 (13.9)	120.4 (10.2)	< 0.001 ^d
Avg. DBP in labor, mm Hg (M (SD)) ^h	92.6 (8.0)	72.3 (7.2)	< 0. 001 ^a
Pre-pregnancy BMI (Mdn (min-max)) ⁱ	25.8 (17-46)	22.9 (16-37)	< 0.001 ^b

Abbreviations: (M (SD)), mean (standard deviation); (Mdn (min-max)), median (minimum-maximum); wks, weeks; Avg. SBP, average systolic blood pressure; mmHg, millimeters of mercury; Avg. DBP, average diastolic blood pressure; BMI, body mass index.
^a Independent samples t-test.
^b Mann–Whitney U test.
^c χ2 test of independence.
^d Independent samples t-test with unequal variance.
^e Outlier removed in controls.
^f n = 168 cases & n = 170 controls.
^g n = 181 cases & n = 173 controls.
^h n = 180 cases & n = 173 controls.
ⁱ BMI values imputed for n = 22 cases, sample size n = 178 cases & n = 172 controls.

ISSN: 1471-2393