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Table 2 Regimens of magnesium sulfate most commonly used in studies

From: An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management

  Pritchard Zuspan Dhaka
Loading 4 g in 20 mL (20% solution) administered IV over 15-20 minutes, followed by 5 g in 10 mL solution (50%) IM injection in each buttock. 4 g in 20 mL (20% solution) administered IV over 15-20 minutes. 4 g in 20 mL (20% solution) administered IV over 15-20 minutes followed by 3 g in 6 mL (50% solution) IM injection in each buttock.
Maintenance 5 g in 10 mL (50% solution) IM injection every 4 hours in alternate buttocks. 1 g/hour IV infusion 2.5 g in 5 mL (50% solution) IM injection every 4 hours in alternate buttocks.
Duration 24 hours after last convulsion or delivery, whichever occurs later
Modifications to standard regimens Modifications included a reduction in the loading dose, or an increase or decrease in the maintenance dose. Some studies also reduced the length of time for which therapy was administered and some stopped therapy after the loading dose.
Two factors affect the amount of magnesium sulfate administered in a course of treatment:
a) duration of labor between the administration of the loading dose and delivery; b) additional convulsions following the loading dose.