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Table 1 Characteristics of the studies and regimens used

From: An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management

Author/year Country Regimen Modification from standard regimen Study Design Randomized (Y/N)
PRITCHARD REGIMENS [12]
Alauddin 2011 [20] India P N/A Prospective cohort N
Bhattarcharjee 2011 [21] India P N/A RCT Y
Pm 4 g loading; 6 g/8 h maintenance
Bhattacharya 2010 [22] India P N/A Case Control N
Bhalla 1994 [23] India Pm 12 g loading RCT Y
Chowdhury 2009 [24] India P N/A RCT Y
   Zm 0.6 g/h maintenance   
Chissell 1994 [25] South Africa P N/A RCT Y
Zm 6 g loading 2 g/h maintenance
Crowther 1990 [26] Zimbabwe P N/A RCT Y
Ekele 2005 [27] Nigeria P N/A Prospective cohort N
Malapaka 2011 [28] India P N/A RCT Y
   Pm 4 g loading; 2 g/3 h maintenance   
Mahajan 2009 [29] India Pm (A) 10 g loading Prospective cohort N
Pm (B) 6 g loading
Manorot 1996 [30] Thailand P N/A RCT Y
Z N/A
Mundle 2011 [31] India P N/A RCT Y
   Z N/A   
Shoaib 2009 [32] Pakistan P N/A Prospective cohort N
   Pm No maintenance dose   
ZUSPAN REGIMENS [33]
Aali 2007 [34] Iran Zm 2 g/h maintenance Prospective cohort N
Belfort 2003 [35] 14 countries Z or Zm 6 g loading; 2 g/h maintenance RCT Y
Coetzee 1998 [36] South Africa Z N/A RCT Y*
Dayicioglu 2003 [37] Turkey Zm 4.5 g loading; 1.8 g/h maintenance Prospective cohort N
Deshmukh 1985 [38] Bangladesh Z or Zm 1 g/h maintenance for 8 h Prospective cohort Y
Dommisse 1988 [39] South Africa Z or Zm 2 g/h maintenance RCT Y
Phuapradit 1993 [40] Thailand Zm 5 g loading Prospective cohort N
PRITCHARD OR ZUSPAN
Altman 2002 [9] 33 countries P or Z N/A RCT Y*
Eclampsia Trial Collaborative Group 1995 [8] 9 countries P or Z1 N/A RCT Y
P or Z2 N/A RCT Y
DHAKA REGIMENS [41]
Begum 2001 [41] Bangladesh D N/A Prospective cohort N
Shilva 2007 [42] India D N/A RCT Y*
   Dm 12 g loading
  1. P = Pritchard; Z = Zuspan; D = Dhaka. Use of “m” after the regimen indicates a modified regimen.
  2. 1 compared against diazepam; 2 compared against phenytoin.
  3. * blinded.