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Table 2 Summary of demographic characteristics of mothers and dosage details (mean ± standard deviation (min-max)

From: Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women

Number of women [N = 75]

Control group [n = 31]

Hypertension group [n = 30]

Diabetes group [n = 14]

  

N = 30

N = 14

Age [years]

31.03 ± 4.13 (23-40)

33.87 ± 5.72 (20-42)

32.14 ± 5.79 (24-41)

Height [m]

1.65 ± 0.078 (1.52–1.81)

1.66 ± 0.059 (1.51–1.80)

1.65 ± 0.065 (1.53–1.78)

Weight [kg]

79.97 ± 14.09 (60–136)

95.71 ± 22.69 (51–142)

87.00 ± 21.51 (60–127)

BSA [m2]*

1.87 ± 0.23 (1.09–2.59)

2.087 ± 0.28 (1.48–2.62)

1.97 ± 0.27 (1.61–2.45)

BMI [kg/m2]**

29.69 ± 6.65 (18.87–41.51)

32.66 ± 7.74 (19.2–43.2)

30.77 ± 7.47 (18.37–42.47)

Systolic pressure (mmHg)

111.3 ± 11.9 (90–130)

150.0 ± 14.3 (130–180) #

120.0 ± 16.4 (90–150)∆

Diastolic pressure (mmHg)

70.6 ± 8.5 (60–80)

96.7 ± 8.8 (80–120) #

73.6 ± 9.3 (60–90) ∆

Dose (mg/kg)

0.063 ± 0.0084 (0.04–0.08)

0.057 ± 0.014 (0.04–0.10)

0.061 ± 0.014 (0.04–0.08)

Dose (mg/m2)

2.66 ± 0.23 (1.93–3.12)

2.45 ± 0.35 (1.91–3.38)

2.58 ± 0.36 (2.04–3.11)

  1. *Boyd ’ s equation BSA = 0.000327 * weight(g)(0.7285 - 0.0188 log10 weight(g)) * height(cm).
  2. ** BMI –body mass index; BMI = weight (kg)/height (m2).
  3. #control group vs. hypertension group, p ≤ 0.05.
  4. ∆hypertension group vs. diabetes group, p ≤ 0.05.