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Table 1 Summary of a) feto: maternal diazepam plasma concentration ratios (C v /C m ); b) umbilical cord arterial: venous diazepam plasma concentration ratios (C a /C v ), and c) times of sample collection t 1 , t 2 and t 3 (min) (mean ± standard deviation (min-max))

From: Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women

Number of women [N = 75]

Control group [n = 31]

Hypertension group [n = 30]

Diabetes group [n = 14]

C v /C m

1.30 ± 0.48 (0.59–2.27)

2.26 ± 1.23 (0.25–4.21)#

2.01 ± 1.10 (0.42–3.77) ##

C a /C v

0.97 ± 0.32 (0.1–1.60)

1.08 ± 0.60 (0.33–2.50)

1.02 ± 0.77 (0.17–2.97)

t 1 (min)

25.9 ± 21.51 (5–118)

28.70 ± 18.18 (10–93)

20.31 ± 11.84 (7–42)

t 2 (min)

60.23 ± 31.87 (18–144)

64.37 ± 22.69 (25–114)

45.38 ± 30.25 (18–138)

t 3 (min)

132.39 ± 42.07 (67–230)

130.40 ± 39.90 (76–278)

122.38 ± 22.61 (92–172)

  1. #control group vs. hypertension group, p ≤ 0.05.
  2. ##control group vs. diabetes group, p ≤ 0.05.