| | | | |
Total folate intake (μg/d)
|
Initiation of preconceptional folic acid supplementation, n (%)
|
|---|
| | |
n
|
(%)
|
median (IQR)
|
p1
|
>8 w
|
0-8 w
|
no
|
p2
|
|
Total
| |
65668
|
(100)
|
266
|
(153–543)
| |
15471
|
(24)
|
12308
|
(19)
|
37889
|
(58)
| |
| |
<25
|
7583
|
(12)
|
228
|
(143–504)
| |
842
|
(11)
|
879
|
(12)
|
5862
|
(77)
| |
|
Maternal age
|
25-29
|
22745
|
(35)
|
275
|
(154–547)
|
<0.0001
|
4990
|
(22)
|
4605
|
(20)
|
13150
|
(58)
|
<0.0001
|
|
in years
|
30-34
|
27782
|
(42)
|
270
|
(155–546)
| |
7475
|
(27)
|
5662
|
(20)
|
14645
|
(53)
| |
| |
>34
|
7558
|
(12)
|
276
|
(160–547)
| |
2164
|
(29)
|
1162
|
(15)
|
4232
|
(56)
| |
|
Pre-
|
<18.5
|
2004
|
(3)
|
294
|
(160–554)
| |
439
|
(22)
|
344
|
(17)
|
1221
|
(61)
| |
|
pregnancy
|
18.5-24.9
|
43198
|
(66)
|
278
|
(157–549)
|
<0.0001
|
10611
|
(25)
|
8388
|
(19)
|
24199
|
(56)
|
<0.0001
|
|
BMI in
|
25-30
|
13448
|
(21)
|
248
|
(148–533)
| |
2999
|
(22)
|
2483
|
(18)
|
7966
|
(59)
| |
|
kg/m2
|
≥30
|
5341
|
(8)
|
229
|
(141–515)
| |
1146
|
(21)
|
822
|
(15)
|
3373
|
(63)
| |
| |
missing
|
1677
|
(3)
|
226
|
(144–491)
| |
276
|
(16)
|
271
|
(16)
|
1130
|
(67)
| |
| |
0
|
33501
|
(51)
|
320
|
(165–566)
| |
8753
|
(26)
|
6031
|
(18)
|
18717
|
(56)
| |
| |
1
|
20743
|
(32)
|
233
|
(146–526)
|
<0.0001
|
4581
|
(22)
|
4466
|
(22)
|
11696
|
(56)
|
<0.0001
|
|
Parity
|
2
|
9199
|
(14)
|
211
|
(144–480)
| |
1752
|
(19)
|
1525
|
(17)
|
5922
|
(64)
| |
| |
3+
|
2140
|
(3)
|
200
|
(140–388)
| |
370
|
(17)
|
272
|
(13)
|
1498
|
(70)
| |
| |
missing
|
85
|
(0,1)
|
183
|
(121–401)
| |
15
|
(18)
|
14
|
(16)
|
56
|
(66)
| |
|
Marital
|
yes
|
63134
|
(96)
|
268
|
(154–544)
|
<0.0001
|
15184
|
(24)
|
12101
|
(19)
|
35849
|
(57)
|
<0.0001
|
|
status
|
no
|
2534
|
(4)
|
232
|
(147–493)
| |
287
|
(11)
|
207
|
(8)
|
2040
|
(81)
| |
|
Maternal
|
<13
|
20618
|
(31)
|
214
|
(138–483)
| |
3237
|
(16)
|
2774
|
(13)
|
14607
|
(71)
| |
|
education
|
13 - 16
|
27249
|
(41)
|
291
|
(157–553)
|
<0.0001
|
6841
|
(25)
|
5601
|
(21)
|
14807
|
(54)
|
<0.0001
|
|
in
|
>16
|
16415
|
(25)
|
331
|
(171–569)
| |
5096
|
(31)
|
3718
|
(23)
|
7601
|
(46)
| |
|
years
|
missing
|
1386
|
(2)
|
243
|
(144–528)
| |
297
|
(21)
|
215
|
(16)
|
874
|
(63)
| |
|
History of
|
no
|
63433
|
(97)
|
267
|
(154–543)
|
<0.0001
|
14980
|
(24)
|
11879
|
(19)
|
36574
|
(58)
|
0.18
|
|
preterm
|
yes
|
2155
|
(3)
|
237
|
(151–521)
| |
472
|
(22)
|
411
|
(19)
|
1272
|
(59)
| |
|
delivery
|
missing
|
80
|
(0,1)
|
252
|
(144–554)
| |
19
|
(24)
|
18
|
(23)
|
43
|
(54)
| |
|
History of
|
no
|
53123
|
(81)
|
269
|
(154–544)
|
<0.0001
|
11655
|
(22)
|
10112
|
(19)
|
31356
|
(59)
|
<0.0001
|
|
abortion
|
yes
|
12545
|
(19)
|
251
|
(150–540)
| |
3816
|
(30)
|
2196
|
(18)
|
6533
|
(52)
| |
| |
never
|
59678
|
(91)
|
277
|
(156–548)
| |
14752
|
(25)
|
11691
|
(20)
|
33235
|
(56)
| |
|
Smoking
|
occasionally
|
1879
|
(3)
|
218
|
(141–453)
|
<0.0001
|
255
|
(14)
|
231
|
(12)
|
1393
|
(74)
|
<0.0001
|
|
habits
|
daily
|
3733
|
(6)
|
190
|
(128–390)
| |
399
|
(11)
|
319
|
(9)
|
3015
|
(81)
| |
| |
missing
|
378
|
(1)
|
221
|
(140–451)
| |
65
|
(17)
|
67
|
(18)
|
246
|
(65)
| |
|
Alcohol
|
no alcohol
|
55368
|
(84)
|
289
|
(159–551)
| |
13360
|
(24)
|
10672
|
(19)
|
31336
|
(57)
| |
|
consumption
|
<0.5
|
6565
|
(10)
|
245
|
(150–528)
|
<0.0001
|
1403
|
(21)
|
1162
|
(18)
|
4000
|
(61)
|
<0.0001
|
|
in units/week
|
≥0.5
|
3735
|
(6)
|
149
|
(117–209)
| |
708
|
(19)
|
474
|
(13)
|
2553
|
(68)
| |
|
Partners with
|
0
|
19439
|
(30)
|
225
|
(143–507)
|
<0.0001
|
3246
|
(17)
|
2853
|
(15)
|
13340
|
(69)
| |
|
income of
|
1
|
26938
|
(41)
|
265
|
(154–542)
|
6287
|
(23)
|
5253
|
(20)
|
15398
|
(57)
|
<0.0001
|
|
>300,000
|
2
|
17472
|
(27)
|
337
|
(169–572)
|
5687
|
(33)
|
3939
|
(23)
|
7846
|
(45)
| |
|
NOK/year
|
missing
|
1819
|
(3)
|
227
|
(147–511)
| |
251
|
(14)
|
263
|
(14)
|
1305
|
(72)
| |
|
Baby's
|
male
|
33445
|
(51)
|
262
|
(152–541)
|
0.003
|
7875
|
(24)
|
6198
|
(19)
|
19372
|
(58)
|
0.3
|
|
sex
|
female
|
32223
|
(49)
|
270
|
(155–545)
| |
7596
|
(24)
|
6110
|
(19)
|
18517
|
(57)
| |
|
Tertiles of
|
1
|
21890
|
(33)
|
179
|
(115–503)
| |
5251
|
(24)
|
4031
|
(18)
|
12608
|
(58)
| |
|
energy intake
|
2
|
21890
|
(33)
|
263
|
(155–548)
|
<0.0001
|
5397
|
(25)
|
4307
|
(20)
|
12186
|
(56)
|
<0.0001
|
|
in MJ
|
3
|
21888
|
(33)
|
325
|
(203–591)
| |
4823
|
(22)
|
3970
|
(18)
|
13095
|
(60)
| |
- Amount of total daily folate intake (FFQ data) and initiation of folic acid supplementation (Q1 data) according to maternal characteristics, from 65,668 participants in the Norwegian Mother and Child Cohort Study (2002 – 2009).
-
1 p-value, estimated with Kruskal-Wallis test.
-
2 p-value, estimated with Pearson's chi-squared test.
