Table 1 Outlines the series of small trials that have evaluated the efficacy of domperidone in mothers of preterm infants
From: Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial)
Study Domperidone | N | Placebo | Randomization | Intervention | Findings |
|---|---|---|---|---|---|
De Leo [18] | 15 | Y | N | 10 mg TID 4d | ↑ lactation |
Petraglia [19] | 17 | Y | N | 10 mg TID 10d | ↑ PRL, BM |
da Silva [20] | 20 | Y | Y | 10 mg TID 7d | ↑ PRL, BM |
Campbell-Yeo [21] | 46 | Y | Y | 10 mg TID 14d | ↑↑ PRL, BM |
Ingram [22] | 80 | Metoclopromide | Y | 10 mg TID 10d | ↑ BM |
Knoppert [23] | 15 | N | Y | 10 mg vs. 20 mg TID 4 weeks | ↑ BM |