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Table 1 Literature review of therapy (excluding amniodrainage alone), presence/absence of hydrops, and other complications in giant chorioangioma cases

From: Prenatal management and perinatal outcome in giant placental chorioangioma complicated with hydrops fetalis, fetal anemia and maternal mirror syndrome

Reference Case # Greatest tumor diameter (mm) Hydrops Other complications Intrauterine therapy Delivery (weeks) Pregnancy outcome
This report 1 78 Yes Polyhidramnios, hydrothorax, mild cardiomegaly, fetal anemia, mirror syndrome Intrauterine transfusion + amniodrainage (29 weeks) 29+6 Neonatal death
Zanardini (2010) 2 42 No Polyhydramnios and cardiomegaly Fetoscopic laser (24+3 weeks) 36+3 Live birth
Zanardini (2010) 3 45 No Moderate cardiomegaly Interstitial laser (25+4 and 26+4 weeks) 32+3 Live birth
Zanardini (2010) 4 35 No Mild cardiomegaly and fetal anemia Interstitial laser (32+3 weeks) 39+1 Live birth
Zanardini (2010) 5 54 No Mild cardiomegaly and fetal anemia Amniodrainage (28+6 weeks) 37+3 Live birth
      Intrauterine blood transfusion (29 weeks)   
      Interstitial laser (29 and 30+4 weeks)   
Sisvali (2009) 1 70 Yes Fetal anemia Intrauterine blood transfusion at 26 27 Live birth
Mendez-Figueroa (2009) 1 43 Yes Fetal anemia Amniodrainage 26 Fetal demise
      Intrauterine blood transfusion   
      Fetoscopy: bipolar and laser coagulation   
Bermúdez (2007) 1 61 Yes Fetal anemia Intrauterine blood transfusion. 27 Fetal demise
      Fetoscopic laser coagulation Amniodrainage   
Deren (2007) 1 83 Yes Fetal anemia Intrauterine blood transfusion. 28 Live birth
      Alcohol injection into the tumor (25 and 26 weeks)   
Quarello (2005) 1 44 Yes No Fetoscopic laser coagulation Amniodrainage 39 Live birth
Escribano D (2005) 1 81 No Fetal anemia Intrauterine blood transfusion (25 weeks, 60 ml) 39 Live birth
Lau (2005) 1 90 Yes Polyhydramnios Ultrasound guided transcutaneous embolisation with enbucrilate (24+2 weeks) 26 Neonatal death
Lau (2003) 1 74 No Fetal anemia Intrauterine blood transfusion (24th weeks, 50 ml) 29 +6 Neonatal death
      Ultrasound-guided transcutaneous embolisation with microcoil (24+2th weeks, 8 pieces)   
      Intrauterine blood transfusion (25th weeks, 60 ml)   
      Ultrasound-guided transcutaneous embolisation with microcoil (25th weeks, 9 pieces)   
      Intrauterine blood transfusion (27th 28th 29th weeks   
Sepúlveda (2003) 1 75 Yes Severe polyhydramnios and cardiac faillure Alcohol ablation (26 weeks) 26 Fetal demise (26 weeks)
Nicolini (1999) 1 60 No Polyhydramnios Amniodrainage N/A Live birth
      Alcohol ablation (27 weeks)   
Nicolini (1999) 2 50 No Polyhidramnios Alcohol ablation (24 and 25 weeks) N/A Live birth
Haak (1999) 1 68 No Fetal anemia Polyhidramnios Intrauterine blood transfusion (30 weeks, 100 ml) 32 Live birth
Quintero (1996) 1 85 Yes Fetal anemia Fetoscopy and devascularisation by suture ligation and bipolar cautery (24th weeks) 24+3 Fetal demise