
FPC1 for mean

FPC2 for mean

FPC3 for mean


Univariate linear regression

Multiple linear regression

Univariate linear regression

Multiple linear regression

Univariate linear regression

Multiple linear regression


Effect (95% CI)

pvalue

Effect (95% CI)

pvalue

Effect (95% CI)

pvalue

Effect (95% CI)

pvalue

Effect (95% CI)

pvalue

Effect (95% CI)

pvalue


Maternal BMI ^{I} categorized

Overweight ^{II}

0.04

0.173

0.11

0.162

−0.18

0.097*

−0.13

0.093

−0.11

0.029**

−0.17

0.028**


(−0.28,1.57)
 
(−0.04,0.26)
 
(−0.39,0.03)
 
(−0.28,0.02)
 
(−0.21,0.01)
 
(−0.31,0.02)
 
Obesity ^{III}

0.09

0.007**

0.25

0.006**

−0.06

0.046**

−0.22

0.014**

0.02

0.711

0.02

0.824


(0.04,2.59)
 
(0.07,0.42)
 
(−0.51,0.01)
 
(−0.40,0.04)
 
(−0.09,0.14)
 
(−0.15,0.20)
 
Primiparity

−0.03

0.353

−0.05

0.383

−0.13

0.119

−0.11

0.082

0.02

0.459

0.06

0.355


(−1.09,0.39)
 
(−0.18,0.07)
 
(−0.30,0.03)
 
(−0.23,0.01)
 
(−0.05,0.11)
 
(−0.06,0.18)
 
Anterior placental site^{b}

0.04

0.183

0.10

0.127

−0.15

<0.001***

−0.32

<0.001***

−0.07

0.026**

−0.15

0.016**


(−0.24,1.25)
 
(−0.03,0.22)
 
(−0.60,0.27)
 
(−0.44, 0.19)
 
(−0.17,0.11)
 
(−0.27,0.03)
 
Gestational age, days

 0.04

0.012**

−0.01

0.006**

0.05

0.111

0.06

0.098

0.06

0.038**

0.08

0.021**


(−0.08,0.01)
 
(−0.17,0.03)
 
(−0.00,0.11)
 
(−0.01, 0.13)
 
(0.00,0.01)
 
(0.00,0.15)
 
 Level of statistical significance * < 0.1, **< 0.05, ***< 0.001.

^{I} Body Mass Index, kg/m^{2}.

^{II} Maternal overweight (25≤BMI<30) versus maternal normal or underweight (BMI <25.00).

^{III} Maternal obesity (30≤BMI) versus maternal normal or underweight (BMI <25.00).

^{b} Predominantly anterior placental site reported from routine ultrasound examination in pregnancy week 18.
 Linear regression with scores on the functional principal components for the smooth curve fits for the mean as the dependent variable and basic pregnancy characteristics as explanatory variables.