Table 6 Sample size required for a range of effect sizes and different hypotheses to be tested
(i) Main effects of treatments versus placebo | (ii) Comparison of pairs of main effects versus one another | (iii) Interactions between pairs of treatments | ||||
|---|---|---|---|---|---|---|
Effect size (% difference in TI) | Full dataset | Reduced dataset* | Full dataset | Reduced dataset* | Full dataset | Reduced dataset* |
5% | 847 | 3388 | 1694 | 3388 | 3388 | 6776 |
7.5% | 385 | 1542 | 771 | 1542 | 1542 | 3084 |
10% | 222 | 888 | 444 | 888 | 888 | 1776 |