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Table 1 Normal Gestational Biology

From: Global report on preterm birth and stillbirth (7 of 7): mobilizing resources to accelerate innovative solutions (Global Action Agenda)

Overarching Goal: To gain comprehensive knowledge of the biology and regulation of human gestational biology in order to identify pathways and critical junctures to facilitate prediction and prevention of preterm birth and stillbirth
  Milestones*  
Output Post-Conference (by 2010) Short-Term (by 2012) Intermediate (by 2015) Long-Term (beyond 2015) Success Metrics
A. Define phenotype of normal pregnancy 1. Systematic review of existing knowledge
2. Develop "best guess" phenotype of normal gestation
3. Prospective tissue repository of normal gestation
4. Utilize "systems biology" technology
5. Identify critical biomarkers, including those governing parturitional stages and biomarkers of placentation, fetal growth and development
6. Develop "lateral flow" multi-analyte diagnostic platforms
7. Begin application of diagnostic tools in LMICs
8. Validate multi-analyte platforms for both HICs and LMICs • Comprehensive atlas of normal human gestation
• Web-based tool for providers and patients
B. Develop animal and in-silico models of normal parturition 1. Systematic review of existing knowledge 2. Explore and develop animal models including genetically altered mice, non-human primates, others
3. Computer modeling
4. Integrate modeling with animal models
5. Validate models
6. Predict outcome based on modeling
7. Use models to predict therapeutic targets and treatments • Improved animal models to identify key regulatory steps
• Enhanced use of in-silico models
C. Define regulators and mechanisms governing stages of parturition 1. Systematic review of existing knowledge 2. Identify critical biomarkers governing parturitional stages and transitions 3. Identify potential therapeutic targets for treatment of PTL
4. Develop therapeutic interventions based upon selected targets
5. Collaborate with Intervention Development to prioritize potential therapeutic interventions
6. Develop therapeutic interventions based upon selected targets and scaling feasibility • Identify novel therapeutic and diagnostic targets
• Web-based tool for providers and patients
  1. *Milestones are to be reached by no later than December of the year indicated.
A GLOBAL ACTION AGENDA ON PRETERM BIRTH AND STILLBIRTH