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Table 2 Incidence of osteoporotic fractures of the subjects between clinical categories

From: Preconception underweight impact on postnatal osteoporotic fracture: a retrospective cohort study using Japanese claims data

 

All (N = 16,684)

(%)

Osteoporotic fracture cases (N = 51)

(%)

Non-fracture or non-Osteoporotic fracture cases (N = 16,633)

(%)

Age at delivery† (years)

      

 Over 40

2936

17.60

11

0.37

2925

99.63

 30 to less than 40

11,490

68.87

36

0.31

11,454

99.69

 20 to less than 30

2255

13.52

4

0.18

2251

99.82

 Less than 20

0

0.00

0

0.00

0

0.00

BMI‡ (kg/m2)

      

 Low (less than 18.5)

3393

20.34

16

0.47

3377

99.53

 Normal (18.5–24.9)

11,405

68.36

29

0.25

11,376

99.75

 Heavy (over 25)

1444

8.65

3

0.21

1441

99.79

Alcohol intake*

      

 Every day

923

5.53

4

0.43

919

99.57

 Not every day

12,823

76.86

35

0.27

12,788

99.73

Smoking⁑

      

 Habitual

1161

6.96

3

0.26

1158

99.74

 Not habitual

13,468

80.72

39

0.29

13,429

99.71

Delivery mode

      

 Caesarean section

4094

24.54

18

0.44

4076

99.56

 Others

12,590

75.46

33

0.26

12,557

99.74

Laboratory findings at the health check

      

Haemoglobin level (g/dL) ⁂

      

 less than 12

1739

10.42

5

0.29

1734

99.71

 more than 12

11,985

71.84

39

0.33

11,946

99.67

Serum T.chol level (mg/dL) ¶

      

 less than 128

188

1.13

1

0.53

187

99.47

 more than 128

14,790

88.65

43

0.29

14,747

99.71

eGFR (mL/min) §

      

 less than 60

54

0.32

1

1.85

53

98.15

 more than 60

9081

54.43

26

0.29

9055

99.71

Complications

      

Diabetes mellitus

      

 yes

389

2.33

1

0.26

388

99.74

 no

16,295

97.67

50

0.31

16,245

99.69

Hypertension

      

 yes

179

1.07

1

0.56

178

99.44

 no

16,505

98.93

50

0.30

16,455

99.70

Hyperlipidaemia

      

 yes

563

3.37

2

0.36

561

99.64

 no

16,121

96.63

49

0.30

16,072

99.70

Hyperparathyroidism

      

 yes

8

0.05

0

0.00

8

100.00

 no

16,625

99.69

51

0.31

16,625

99.69

Hyperthyroidism

      

 yes

281

1.68

0

0.00

281

100.00

 no

16,403

98.32

51

0.31

16,352

99.69

Hypogonadism

      

 yes

5605

33.60

18

0.32

5587

99.68

 no

11,079

66.40

33

0.30

11,046

99.70

Anorexia nervosa

      

 yes

22

0.13

1

4.55

21

95.45

 no

16,662

99.87

50

0.30

16,612

99.70

Reflux esophagitis

      

 yes

1103

6.61

4

0.36

1099

99.64

 no

15,581

93.39

47

0.30

15,534

99.70

Gynaecologic malignancies and breast cancer

      

 yes

60

0.36

0

0.00

60

100.00

 no

16,624

99.64

51

0.31

16,573

99.69

  1. BMI, body mass index; eGFR, estimated glomerular filtration rate; Hb, haemoglobin; T.chol, total cholesterol; †ages were missed in 3 unfractured cases; ‡ body mass index was missed in 3 fracture cases and in 439 unfractured cases; ⁑ information about smoking was missed in 9 fracture cases and in 2,046 unfractured cases; habitual smoking is defined as a smoking habit of a total of 100 or more cigarettes or smoking for more than 6 months at the time of the health check; * information about alcohol was missed in 12 fracture cases and in 2,926 unfractured cases; ⁂ information about laboratory findings of the haemoglobin level was missed in 7 fracture cases and in 2,953 unfractured cases; ¶ information about laboratory findings of the serum total cholesterol level was missed in 7 fracture cases and in 1,699 unfractured cases; § information about the estimated glomerular filtration rate was missed in 24 fracture cases and in 7,525 unfractured cases