Table 1 Characteristics of the study population with or without acetaminophen use during prenancy
Characteristics | Before matching (n = 41,440) | After matching (n = 1002) | ||||
|---|---|---|---|---|---|---|
Acetaminophen use (n = 501) | Control (n = 40,939) | p value | Acetaminophen use (n = 501) | Control (n = 501) | p value | |
Maternal age (median and IQR) | 32 (30–35) | 33 (30–35) | 0.005 | 32 (30–35) | 32 (30–35) | 0.991 |
Pre-pregnancy BMI, kg/m2n (%) | 0.003 | 0.158 | ||||
Underweight (< 18.5) | 18 (3.59) | 2124 (5.19) | 18 (3.59) | 7 (1.40) | ||
Normal weight (18.5–24.9) | 211 (42.12) | 14,196 (34.68) | 211 (42.12) | 209 (41.72) | ||
Overweight (25.0−29.9) | 116 (23.15) | 9733 (23.77) | 116 (23.15) | 124 (24.75) | ||
Obese (≥ 30.0) | 156 (31.14) | 14,886 (36.36) | 156 (31.14) | 161 (32.13) | ||
Number of previous pregnancies (median and IQR) | 1(0–2) | 1(0–2) | < 0.001 | 1(0–2) | 1(0–2) | 0.779 |
1 | 187 (37.33) | 10,699 (26.13) | 187 (37.33) | 176 (35.13) | ||
≥ 2 | 314 (62.67) | 30,240 (73.87) | 314 (62.67) | 325 (64.87) | ||
Previous live births (median and IQR) | 0(0–1) | 1(0–1) | < 0.001 | 0(0–1) | 0(0–1) | 0.820 |
0 | 281 (56.09) | 16,426 (40.12) | 281 (56.09) | 282 (56.29) | ||
≥ 1 | 220 (43.91) | 24,513 (59.88) | 220 (43.91) | 219 (43.71) | ||
History of adverse pregnancy outcomes n (%) | 0.063 | 0.250 | ||||
Yes | 68 (13.57) | 4485 (10.96) | 68 (13.57) | 56 (11.18) | ||
No | 433 (86.43) | 36,454 (89.04) | 433 (86.43) | 445 (88.82) | ||
Type of labour n (%) | < 0.001 | 0.955 | ||||
Spontaneous | 224 (44.71) | 22,282 (54.43) | 224 (44.71) | 222 (44.31) | ||
Caesarean section | 254 (50.70) | 16,478 (40.25) | 254 (50.70) | 254 (50.70) | ||
Induced | 23 (4.59) | 2179 (5.32) | 23 (4.59) | 25 (4.99) | ||
Infection with COVID−19 n (%) | < 0.001 | 0.446 | ||||
Yes | 25 (4.99) | 308 (0.75) | 25 (4.99) | 20 (3.99) | ||
No | 476 (95.01) | 40,631 (99.25) | 476 (95.01) | 481 (96.01) | ||
Comorbidities* n (%) | < 0.001 | 0.558 | ||||
Yes | 314 (62.67) | 10,477 (25.59) | 314 (62.67) | 305 (60.88) | ||
No | 187 (37.33) | 30,462 (74.41) | 187 (37.33) | 196 (39.12) | ||
Co-medication#n (%) | < 0.001 | 0.335 | ||||
Yes | 357 (71.26) | 16,170 (39.50) | 357 (71.26) | 343 (68.46) | ||
No | 144 (28.74) | 24,769 (60.50) | 144 (28.74) | 158 (31.54) | ||