Table 3 Frequencies of secondary outcomes of the index pregnancy in each treatment group
Secondary Outcomes | Total (N = 637) | Any Progesterone (N = 353) | ap-value | 17-OHPC (N = 296) | bp-value | Vaginal Progesterone (N = 42) | cp-value | No treatment (N = 287) |
|---|---|---|---|---|---|---|---|---|
Recurrent preterm birth (20 0/7- < 37 weeks) | 161 (25.3) | 99 (27.7) | 0.1453 | 86 (29.1) | 0.07666 | 6 (14.3) | 0.3254 | 64 (22.3) |
Recurrent preterm birth (20 0/7—< 34 weeks) | 59 (9.3) | 40 (11.4) | 0.04774 | 35 (11.8) | 0.04297 | 3 (7.1) | 1 | 19 (6.6) |
Recurrent preterm birth (20 0/7—< 28 weeks) | 21 (3.3) | 14 (4.0) | 0.371 | 13 (4.4) | 0.2857 | 0 (0.0) | 0.6523 | 7 (2.5) |
Recurrent preterm birth (20 0/7—< 24 weeks) | 8 (1.3) | 4 (1.1) | 1 | 0 (0.0) | 1 | 0 (0.0) | 0.9854 | 8 (2.3) |
Latency (days) | 50.2 ± 38.97 | < 0.001 | 49.6 ± 39.4 | < 0.001 | 51.7 ± 37.4 | < 0.001 | 32.98 ± 37.9 | |
Second trimester loss (< 20 weeks) | 8 (1.2) | 0 (0.0) | 0.005563 | 0 (0.0) | 0.0112 | 0 (0.0) | 0.5761 | 8 (1.2) |
First trimester loss (< 14 weeks) | 0 (0.0) | 0 (0.0) | – | 0 (0.0) | – | 0 (0.0) | – | 0 (0.0) |
Preeclampsia | 69 (10.8) | 34 (9.8) | 0.3722 | 27 (9.1) | 0.2585 | 6 (14.3) | 0.8885 | 35 (12.2) |
Gestational age at delivery (weeks) | 37.0 ± 3.9 | 37.0 ± 3.4 | 0.9542 | 36.9 ± 3.5 | 0.8699 | 37.9 ± 2.0 | 0.1856 | 36.9 ± 4.5 |
Birthweight (grams) | 2991.7 ± 731.2 | 2956.8 ± 728.7 | 0.2344 | 2972.6 ± 723.4 | 0.3395 | 2895.4 ± 699.6 | 0.2601 | 3031.0 ± 729.7 |
1 min Apgar (0–9) | 7.7 ± 1.9 | 7.7 ± 1.9 | 0.5895 | 7.6 ± 1.9 | 0.3538 | 8.2 ± 0.8 | 0.1332 | 7.8 ± 1.9 |
5-min Apgar (0–9) | 8.5 ± 1.4 | 8.6 ± 1.3 | 0.9179 | 8.5 ± 1.4 | 0.8385 | 8.9 ± 0.4 | 0.1476 | 8.5 ± 1.6 |
Neonatal demise (demise within 30 DOL) | 11 (1.7) | 7 (2.0) | 0.7728 | 7 (2.4) | 0.5824 | 0 (0.0) | 0.9831 | 4 (1.4) |
Cesarean delivery | 224 (35.3) | 128 (36.9) | 0.3703 | 110 (37.1) | 0.3473 | 12 (28.6) | 0.6509 | 95 (33.1) |
NICU admission | 181 (28.5) | 108 (31.1) | 0.08675 | 94 (31.8) | 0.0715 | 11 (26.2) | 0.9417 | 72 (25.1) |
Respiratory Distress Syndrome | 32 (5.0) | 23 (3.6) | 0.2602 | 18 (6.8) | 0.2735 | 2 (4.8) | 1 | 11 (3.0) |
Bronchopulmonary Dysplasia | 7 (1.1) | 4 (0.6) | 1 | 3 (1.0) | 1 | 0 (0.0) | 1 | 3 (1.0) |
Grade III-IV Intraventricular hemorrhage | 2 (0.3) | 1 (0.2) | 1 | 1 (0.3) | 1 | 0 (0.0) | 1 | 1 (0.3) |
Necrotizing Enterocolitis | 1 (0.2) | 1 (0.2) | 1 | 1 (0.3) | 1 | 0 (0.0) | – | 0 (0.0) |
Sepsis | 5 (0.8) | 4 (0.6) | 1 | 3 (1.0) | 1 | 0 (0.0) | 1 | 2 (0.7) |
Length of NICU stay (days) | 6.8 ± 18.3 | 7.7 ± 19.2 | 0.3139 | 8.2 ± 19.7 | 0.2002 | 2.2 ± 6.1 | 0.1998 | 5.9 ± 17.4 |
Length of hospital stay (days) | 4.1 ± 4.0 | 4.3 ± 4.8 | 0.05204 | 4.2 ± 4.2 | 0.07702 | 3.9 ± 2.6 | 0.728 | 3.7 ± 2.5 |