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Table 3 Clinical characteristics with respect to the HBV DNA levels of HBsAg-positive pregnant women

From: The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study

 

 < 103 IU/ml

103–106 U/ml

 > 106 IU/ml

Subjects (n)

55

46

92

Gestational age (weeks)

36.65 ± 2.15

36.00 ± 3.00

35.66 ± 2.69a

Peak TBA level (µmol/L)

41.5(28.05–61.85)

53.4(30.63–115.03)

67.3(44–108.8)a

ALT (U/L)

16(10.5–21.5)

59.5(19–402.98)a

198(56–517)a

AST (U/L)

20(16–27.5)

50.5(23.5–365)a

181(41–430)a

TBIL (µmol/L)

6.8(4.65–8.85)

10.05(6.1–17.6)a

10.4(7.15–45.45)a

Preterm birth (n%)

15(27.3%)

22(47.8%)a

53(57.6%)a

MSAF (n%)

9(16.4%)

13(28.3%)

27(29.3%)a

Birth weight (g)

2795.42 ± 491.67

2787.73 ± 468.78

2600.94 ± 531.78a

Birth height (cm)

47.40 ± 3.36

47.16 ± 3.24

46.17 ± 3.28a

Apgar score (1 min)

9.92 ± 0.34

9.75 ± 0.611

9.64 ± 1.51

Admitted to the NICU (n%)

24(43.6%)

27(58.7%)a

62(67.4%)ab

Intrauterine death (n%)

1(1.8%)

0

2(2.2%)

  1. Normal distribution measurement data were expressed as mean ± SD and analyzed by analysis of variance. Non-normal distribution measurement data were expressed as median (interquartile range) and analyzed by Kruskal–Wallis H test; The frequency of preterm birth, MSAF, asphyxia neonatorum, admitted to the NICU and intrauterine death were compared by Chi-square tests or Fisher’s exact tests
  2. Abbreviations: TBA total bile acid, ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, MSAF meconium-stained amniotic fluid, NICU neonatal intensive care unit
  3. aP < 0.05: Compared to the low viral load (< 103 IU/mL) group; bP < 0.05: Compared to the medium viral load (103–106 U/mL) group