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Table 2 Clinical characteristics with respect to HBeAg status among HBsAg-positive pregnant women

From: The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study

 

HBeAg positivity

HBeAg negativity

P value

Subjects (n)

102

91

 

Gestational age (weeks)

35.75 ± 2.83

36.43 ± 2.44

0.021

ALT (U/L)

187(44.5–421.5)

19(13–127.5)

0.000

AST (U/L)

136.35(32–361.75)

23(17.75–23.00)

0.000

ALT > 40U/L(n%)

77(75.5%)

31(33.0%)

0.000

TBIL (µmol/L)

10.25(6.13–19.85)

7.65(5.65–11.65)

0.015

TBA (µmol/L)

69.8(44–115.7)

46.4(26.8–46.4)

0.000

Preterm birth (n%)

46(45.1%)

32(35.2%)

0.160

MSAF (n%)

34(33.3%)

68(66.7%)

0.079

Birth height (cm)

46.33 ± 3.34

47.35 ± 3.01

0.038

Birth weight (g)

2596.52 ± 523.03

2840.24 ± 520.56

0.002

Apgar score (1 min)

9.70 ± 1.035

9.87 ± 0.56

0.195

Admitted to the NICU (n%)

70(68.6%)

48(52.7%)

0.024

Intrauterine death (n%)

2(2.0%)

1(1.1%)

0.629

  1. Normal distribution measurement data were expressed as mean ± SD and analyzed by t test. Non-normal distribution measurement data were expressed as median (interquartile range) and analyzed by Mann–Whitney U test; The frequency of preterm birth, MSAF, asphyxia neonatorum, admitted to the NICU and intrauterine death were compared by Chi-square tests or Fisher’s exact tests
  2. Abbreviations: TBA, total bile acid, ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, MSAF meconium-stained amniotic fluid, NICU, neonatal intensive care unit