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Table 1 Clinical characteristics of the different groups

From: The effect of intrahepatic cholestasis in pregnancy combined with different stages of hepatitis B virus infection on pregnancy outcomes: a retrospective study

 

Group I

Group II

Group III

 

(ICP)

(ICP + HBV with abnormal liver function)

(ICP + HBV with normal liver function)

Subjects (n)

319

113

80

Maternal age (years)

29.56 ± 4.27

30.1 ± 4.65

30.81 ± 4.7

Gestational age (weeks)

37.12 ± 2.38a

35.81 ± 2.76

37.31 ± 2.17a

Prepregnancy BMI (kg/m2)

20.36 ± 2.81

20.32 ± 2.35

20.31 ± 2.94

BMI at delivery (kg/m2)

25.03 ± 2.99

24.61 ± 2.77

24.81 ± 2.99

TBA (µmol/L)

37.65(25.13–53.69)a

71.5(47.39–123.03)

42.7(25.55–61.5)a

ALT (U/L)

14(10–29)a

96.25(276.5–554.75)

18(13–23.5)a

AST (U/L)

19(16–29)a

224(70–488.5)

21(16.75–27.25)a

TBIL (µmol/L)

7.15(5.1–10.1)a

12(7–25.7)

7(4.88–9.4)a

Preterm birth (n%)

117(36.7%)a

71(62.80%)

23(28.7%)a

MSAF (n%)

32(10.03%)a

34(30.09%)

9(11.25%)a

Birth height (cm)

47.14 ± 3.1

46.03 ± 3.16

47.72 ± 3.47

Birth weight (g)

2782.4 ± 560.3

2594.3 ± 527.6

2867.07 ± 512.2

Apgar score (1 min)

9.75 ± 0.9a

9.67 ± 1.06

9.93 ± 0.3a

Asphyxia neonatorum (n%)

6(1.88%)

2(1.77%)

0(0.0%)

Admitted to the NICU (n%)

155(48.59%)

86(76.11%)

32(40.00%)a

Intrauterine death (n%)

2(0.6%)

2(1.8%)

1(0.1%)

  1. Normal distribution measurement data were expressed as mean ± SD and analyzed by analysis of variance. Non-normal distribution measurement data were expressed as median (interquartile range) and analyzed by Kruskal–Wallis H test; The frequency of preterm birth, MSAF, asphyxia neonatorum, admitted to the NICU and intrauterine death were compared by Chi-square tests or Fisher’s exact tests
  2. Abbreviations: BMI body mass index, TBA total bile acid, ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, MSAF meconium-stained amniotic fluid, NICU neonatal intensive care unit
  3. aP < 0.05, compared with Group II