Table 1 Effects of prenatal drug exposure on fetal blood flow metrics & associated effect sizes. Table of blood flow metric comparisons & associated effect sizes (Hedge’s g, reported as Effect Size [95% CI upper, lower limits]). Bold text indicates accompanying p-value < 0.05. Italicized text indicates accompanying p-value < 0.1

MCA

G11

0.0207

0.0006

0.078 [-1.715, 1.871]

0.628 [-0.411, 1.667]

0.49 [-0.54, 1.519]

G13.5

1.195 [0.094, 2.295]

1.279 [0.166, 2.391]

0.717 [-0.33, 1.763]

G16

1.374 [0.247, 2.502]

1.267 [0.156, 2.378]

1.735 [0.546, 2.924]

ICA

G11

0.0022

0.0306

0.448 [-0.579, 1.475]

0.065 [-0.95, 1.079]

0.176 [-0.84, 1.192]

G13.5

1.209 [0.106, 2.311]

0.22 [-0.797, 1.237]

0.69 [-0.354, 1.734]

G16

0.84 [-0.218, 1.897]

0.692 [-0.352, 1.736]

1.919 [0.694, 3.144]

UA

G11

0.6007

0.7432

0.121 [-0.894, 1.136]

0.22 [-0.797, 1.238]

0.186 [-0.83, 1.203]

G13.5

0.897 [-0.167, 1.961]

0.812 [-0.243, 1.867]

0.829 [-0.227, 1.886]

G16

0.514 [-0.516, 1.545]

0.23 [-0.788, 1.248]

0.592 [-0.444, 1.629]

Acceleration

Main effect: exposure

Interaction: exposure x day

Hedge’sg:

CON vs. ALC

Hedge’sg:

CON vs. CB

Hedge’sg:

CON vs. ALC + CB

p-value

p-value

MCA

G11

0.0011

0.0994

0.267 [-0.441, 0.975]

0.193 [-0.51, 0.895]

0.006 [-0.701, 0.714]

G13.5

1.114 [0.024, 2.204]

0.961 [0.239, 1.682]

1.615 [0.853, 2.377]

G16

1.402 [0.271, 2.534]

1.447 [0.733, 2.162]

1.319 [0.612, 2.026]

ICA

G11

0.0874

0.3412

0.577 [0.408, 0.746]

0.179 [-0.521, 0.878]

0.337 [-0.375, 1.048]

G13.5

0.629 [0.431, 0.828]

0.452 [-0.257, 1.161]

0.427 [-0.276, 1.129]

G16

0.347 [-0.353, 1.047]

0.713 [0.012, 1.415]

1.134 [0.432, 1.836]

UA

G11

0.5798

0.8334

0.205 [-0.542, 0.951]

0.101 [-0.914, 1.116]

0.148 [-0.868, 1.164]

G13.5

0.968 [0.21, 1.727]

0.415 [-0.61, 1.44]

1.756 [0.563, 2.949]

G16

0.033 [-0.715, 0.78]

0.384 [-0.639, 1.408]

0.355 [-0.667, 1.377]

Peak Systolic Velocity

Main effect: exposure

Interaction: exposure x day

Hedge’sg:

CON vs. ALC

Hedge’sg:

CON vs. CB

Hedge’sg: CON vs. ALC + CB

p-value

p-value

MCA

G11

0.0437

0.011

0.044 [-0.879, 0.967]

0.454 [-0.423, 1.331]

0.431 [-0.442, 1.304]

G13.5

0.837 [-0.221, 1.895]

0.779 [-0.252, 1.81]

0.302 [-0.529, 1.132]

G16

1.189 [0.089, 2.289]

1.247 [0.339, 2.155]

1.277 [0.421, 2.132]

ICA

G11

0.0263

0.0326

0.103 [-0.737, 0.942]

0.823 [-0.057, 1.704]

0.513 [-0.458, 1.483]

G13.5

1.209 [0.23, 2.188]

0.487 [-0.627, 1.601]

0.615 [-0.24, 1.469]

G16

0.766 [-0.07, 1.602]

0.652 [-0.132, 1.437]

1.601 [0.751, 2.451]

UA

G11

0.5708

0.5999

0.232 [-0.603, 1.067]

0.294 [-0.726, 1.313]

0.403 [-0.621, 1.428]

G13.5

0.888 [-0.074, 1.85]

0.7 [-0.345, 1.745]

1.158 [0.062, 2.253]

G16

0.445 [-0.401, 1.29]

0.342 [-0.679, 1.364]

0.58 [-0.455, 1.616]