Fig. 2

Drug-associated changes in fetal blood flow in the middle cerebral and internal carotid arteries. A) Representative examples of systolic pulse waveforms from the fetal middle cerebral artery across drug groups on Gestational Day 16. B) Velocity-Time Integral measurements from the fetal middle cerebral artery across drug groups and assessment days. C) Within-fetus changes in middle cerebral artery Velocity-Time Integral measurements across drug groups and assessment days. D) Representative examples of systolic pulse waveforms from the fetal internal carotid artery across drug groups on Gestational Day 16. E) Velocity-Time Integral measurements from the fetal internal carotid artery across drug groups and assessment days. F) Within-fetus changes in internal carotid artery Velocity-Time Integral measurements across drug groups and assessment days. Abbreviations: G = Gestational Day, MCA = Middle Cerebral Artery, ICA = Internal Carotid Artery, VTI = Velocity-Time Integral, CON = Control, ALC = Alcohol, CB = Cannabinoid, ALC + CB = Alcohol + Cannabinoid. Symbols: Green # indicates a statistically significant change from 0. * indicates p < 0.05, ** indicates p < 0.01, *** indicates p < 0.001, **** indicates p < 0.0001