Table 4 Association between maternal genotypes and the risk of CHDs

UGT1A7

rs11692021

Log-additive

-

-

-

0.79(0.56–1.11)

0.1754

0.7015

Dominant

T/T

154(57.46)

159(64.9)

1

T/C-C/C

114(42.54)

86(35.1)

0.75(0.49–1.13)

0.1632

0.6298

Recessive

T/T-T/C

252(94.03)

234(95.51)

1

C/C

16(5.97)

11(4.49)

0.78(0.31–1.93)

0.5863

0.7818

UGT1A7

rs4124874

Log-additive

-

-

-

1.74(1.28–2.37)

0.0004

0.009*

Dominant

T/T

142(52.99)

96(39.18)

1

T/G-G/G

126(47.01)

149(60.82)

1.86(1.25–2.78)

0.0023

0.0469*

Recessive

T/T-T/G

250(93.28)

208(84.9)

1

G/G

18(6.72)

37(15.1)

2.50(1.26–4.94)

0.0085

0.1253

UGT1A7

rs10929302

Log-additive

-

-

-

1.23(0.80–1.90)

0.3456

0.7325

Dominant

G/G

215(80.22)

194(79.18)

1

G/A-A/A

53(19.78)

51(20.82)

1.04(0.64–1.70)

0.8754

0.9423

Recessive

G/G-G/A

267(99.63)

236(96.33)

1

 A/A

1(0.37)

9(3.67)

13.66(1.54–121)

0.0188

0.1253

UGT1A7

rs887829

Log-additive

-

-

-

1.22 (0.79–1.88)

0.3663

0.7325

Dominant

C/C

214(79.85)

194(79.18)

1

C/T-T/T

54(20.15)

51(20.82)

1.03(0.63–1.68)

0.9094

0.9423

Recessive

C/C-C/T

267(99.63)

236(96.33)

1

T/T

1(0.37)

9(3.67)

13.66(1.54–121)

0.0188

0.1253

UGT1A7

rs4148323

Log-additive

-

-

-

0.69 (0.47–1.01)

0.0577

0.5055

Dominant

G/G

174(64.93)

181(73.88)

1

G/A-A/A

94(35.07)

64(26.12)

0.70(0.45–1.08)

0.1095

0.6298

Recessive

G/G-G/A

255(95.15)

240(97.96)

1

 A/A

13(4.85)

5(2.04)

0.38 (0.11–1.29)

0.1199

0.5994

UGT2B15

rs3100

Log-additive

-

-

-

1.38 (0.95–2.01)

0.0888

0.5055

Dominant

G/G

193(72.01)

160(65.31)

1

G/A-A/A

75(27.99)

85(34.69)

1.41 (0.92–2.16)

0.1113

0.6298

Recessive

G/G-G/A

262(97.76)

238(97.14)

1

 A/A

6(2.24)

7(2.86)

1.83(0.55–6.10)

0.3281

0.7149

UGT2B15

rs4148269

Log-additive

-

-

-

1.37(0.94–1.99)

0.1011

0.5055

Dominant

T/T

192(71.64)

160(65.31)

1

T/G-G/G

76(28.36)

85(34.69)

1.39(0.91–2.13)

0.1284

0.6298

Recessive

T/T-T/G

262(97.76)

238(97.14)

1

G/G

6(2.24)

7(2.86)

1.83(0.55–6.10)

0.3281

0.7149

UGT2B15

rs2045100

Log-additive

-

-

-

0.93(0.68–1.26)

0.6269

0.7973

Dominant

T/T

125(46.64)

119(48.57)

1

T/A-A/A

143(53.36)

126(51.43)

0.89(0.60–1.33)

0.5612

0.9423

Recessive

T/T-T/A

244(91.04)

223(91.02)

1

 A/A

24(8.96)

22(8.98)

0.97(0.50–1.88)

0.9232

1

UGT2B15

rs1902023

Log-additive

-

-

-

0.93 (0.71–1.23)

0.6104

0.7973

Dominant

C/C

84(31.34)

85(34.69)

1

C/A-A/A

184(68.66)

160(65.31)

0.97(0.64–1.48)

0.8849

0.9423

Recessive

C/C-C/A

208(77.61)

200(81.63)

1

 A/A

60(22.39)

45(18.37)

0.83(0.51–1.36)

0.4569

0.7149

UGT2B15

rs9994887

Log-additive

-

-

-

0.96(0.73–1.26)

0.7578

0.7973

Dominant

G/G

85(31.72)

83(33.88)

1

G/A-A/A

183(68.28)

162(66.12)

1.02 (0.67–1.56)

0.916

0.9423

Recessive

G/G-G/A

208(77.61)

199(81.22)

1

 A/A

60(22.39)

46(18.78)

0.84(0.52–1.38)

0.5004

0.7149

UGT2B15

rs13112099

Log-additive

-

-

-

0.96(0.73–1.26)

0.7578

0.7973

Dominant

G/G

85(31.72)

83(33.88)

1

G/T-T/T

183(68.28)

162(66.12)

1.02(0.67–1.56)

0.916

0.9423

Recessive

G/G-G/T

208(77.61)

199(81.22)

1

T/T

60(22.39)

46(18.78)

0.84(0.52–1.38)

0.5004

0.7149

UGT2B15

rs7686914

Log-additive

-

-

-

1.04(0.79–1.37)

0.7578

0.7973

Dominant

T/T

60(22.39)

46(18.78)

1

T/C-C/C

208(77.61)

199(81.22)

1.19(0.72–1.94)

0.916

0.9423

Recessive

T/T-T/C

183(68.28)

162(66.12)

1

C/C

85(31.72)

83(33.88)

0.98(0.64–1.49)

0.5004

0.7149

UGT2B15

rs7696472

Log-additive

-

-

-

1.05(0.80–1.38)

0.7415

0.7973

Dominant

G/G

60(22.39)

46(18.78)

1

G/A-A/A

208(77.61)

199(81.22)

1.19(0.72–1.94)

0.9423

0.9423

Recessive

G/G-G/A

183(68.28)

161(65.71)

1

 A/A

85(31.72)

84(34.29)

0.98(0.65–1.50)

0.5004

0.7149

UGT2B7

rs4587017

Log-additive

-

-

-

0.83(0.61–1.13)

0.228

0.7325

Dominant

T/T

19(7.09)

22(8.98)

1

T/G-G/G

249(92.91)

223(91.02)

0.71(0.35–1.45)

0.2988

0.8538

Recessive

T/T-T/G

121(45.15)

115(46.94)

1

G/G

147(54.85)

130(53.06)

0.81(0.54–1.21)

0.3473

0.7149

UGT2B7

rs7662029

Log-additive

-

-

-

0.85(0.62–1.16)

0.2996

0.7325

Dominant

A/A

19(7.09)

22(8.98)

1

 A/G-G/G

249(92.91)

223(91.02)

0.71(0.35–1.45)

0.4125

0.9423

Recessive

A/A-A/G

125(46.64)

116(47.35)

1

G/G

143(53.36)

129(52.65)

0.85(0.57–1.26)

0.3473

0.7149

UGT2B7

rs12233719

Log-additive

-

-

-

0.94(0.65–1.36)

0.7391

0.7973

Dominant

G/G

184(68.66)

177(72.24)

1

G/T-T/T

84(31.34)

68(27.76)

0.95 (0.62–1.46)

0.8184

0.9423

Recessive

G/G-G/T

259(96.64)

238(97.14)

1

T/T

9(3.36)

7(2.86)

0.79(0.25–2.45)

0.6793

0.8491

UGT2B7

rs10028494

Log-additive

-

-

-

1.14(0.80–1.62)

0.4861

0.7973

Dominant

A/A

166(61.94)

152(62.04)

1

 A/C-C/C

102(38.06)

93(37.96)

1.10(0.73–1.66)

0.658

0.9423

Recessive

A/A-A/C

260(97.01)

236(96.33)

1

C/C

8(2.99)

9(3.67)

1.69(0.58–4.94)

0.3395

0.7149

CYP2C19

rs12248560

Log-additive

-

-

-

0.82(0.22–3.12)

0.7719

0.7973

Dominant

C/C

262(97.76)

239(97.55)

1

C/T-T/T

6(2.24)

6(2.45)

0.82(0.22–3.12)

0.7719

0.9423

Recessive

C/C-C/T

268(100)

245(100)

1

T/T

0(0)

0(0)

NA

NA

NA

CYP2C19

rs4244285

Log-additive

-

-

-

0.96(0.72–1.29)

0.7973

0.7973

Dominant

G/G

118(44.03)

108(44.08)

1

G/A-A/A

150(55.97)

137(55.92)

0.92(0.62–1.37)

0.6817

0.9423

Recessive

G/G-G/A

239(89.18)

213(86.94)

1

 A/A

29(10.82)

32(13.06)

1.03(0.56–1.90)

0.9237

1

CYP2C9

rs1057910

Log-additive

-

-

-

1.58(0.72–3.47)

0.2585

0.7325

Dominant

A/A

256(95.52)

225(91.84)

1

 A/C-C/C

12(4.48)

20(8.16)

1.76(0.76–4.08)

0.189

0.6298

Recessive

A/A-A/C

267(99.63)

245(100)

1

C/C

1(0.37)

0(0)

0(0-inf)

0.9993

1