Table 1 Clinical characteristics of the pregnancies with fetuses affected by hemoglobin Bart’s disease and those with non-anemic fetuses

Baseline characteristics

Maternal age (years): mean ± SD

26.3 ± 4.5

28.8 ± 5.9

Parity; nulliparity : N (%)

13 (76.5%)

9 (69.2%)

Gestational age at sampling (weeks): mean ± SD

19.4 ± 2.7

19.6 ± 2.9

Biparietal diameter (cm): mean ± SD

4.5 ± 0.8

4.6 ± 1.0

Hemoglobin (g/dl): mean ± SD

6.4 ± 1.3

11.2 ± 1.2

Hematocrit (%): mean ± SD

26.9 ± 5.6

37.1 ± 3.8

Cardiac morphology

Cardio-thoracic diameter ratio : mean ± SD

0.60 ± 0.07

0.45 ± 0.04

Cardio-thoracic area ratio : mean ± SD

0.39 ± 0.07

0.26 ± 0.04

Left ventricular wall thickness (mm) : mean ± SD

1.77 ± 0.49

1.69 ± 0.45

Right ventricular wall thickness (mm) : mean ± SD

1.78 ± 0.45

1.57 ± 0.53

Global sphericity index (GSI): mean ± SD

1.07 ± 0.21

1.27 ± 0.12

Cardiac function

Combined cardiac output Z-score: mean ± SD

1.55 ± 0.77

0.95 ± 0.48

Right myocardial performance index: mean ± SD

0.57 ± 0.13

0.48 ± 0.10

Right isovolumic contraction time: mean ± SD

45.44 ± 14.10

35.56 ± 10.31

Right isovolumic relaxation time: mean ± SD

48.50 ± 10.12

46.48 ± 7.47

Right ejection time: mean ± SD

154.56 ± 14.95

152.31 ± 13.69

Left myocardial performance index: mean ± SD

0.55 ± 0.13

0.49 ± 0.11

Left isovolumic contraction time: mean ± SD

48.44 ± 16.97

33.38 ± 11.99

Left isovolumic relaxation time: mean ± SD

44.39 ± 9.50

45.15 ± 7.41

Left ejection time: mean ± SD

157.67 ± 12.63

157.54 ± 13.18

Right shortening fraction (%): mean ± SD

35 ± 7

40 ± 11

Left shortening fraction (%): mean ± SD

39 ± 13

39 ± 9

Ductus venosus preload index: mean ± SD

0.50 ± 0.25

0.48 ± 0.15

Cerebral circulation

MCA-PSV (cm/sec): mean ± SD

38.88 ± 8.05

26.97 ± 11.58

MCA-PSV (MoMs): mean ± SD

1.56 ± 0.52

0.85 ± 0.43

MCA-PI: mean ± SD

1.31 ± 0.26

1.51 ± 0.23