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Table 5 Rates of respiratory distress syndrome (RDS) at 32–36 weeks and 37–38 weeks per 1000 fetuses at risk and unadjusted odds ratios and 95 % confidence intervals (CI) expressing the association between maternal and infant characteristics and RDS, United States, 2005–2006

From: Heterogeneity of respiratory distress syndrome: risk factors and morbidity associated with early and late gestation disease

Risk factors

RDS 32–36 weeks

RDS 37–38 weeks

Cases

Fetuses at risk

Rate/1000a

Odds ratiosb [95 % CI]

Cases

Fetuses at risk

Rate/1000a

Odds ratiosb [95 % CI]

Age

<20 years

1165

426,327

2.7

1.00 [0.94, 1.06]

360

386,323

0.93

0.83 [0.74, 0.92]

20–34

8969

3,265,775

2.7

Reference

3364

2,978,793

1.13

Reference

≥35

1808

610,342

3.0

1.03 [1.01, 1.04]

568

545,748

1.04

0.97 [0.95, 1.00]

Multi-fetal gestation

2770

133,526

20.7

9.61 [9.21, 10.0]

214

55,869

3.83

3.63 [3.16, 4.17]

Smoking

1613

441,604

3.7

1.37 [1.30, 1.44]

632

392,595

1.61

1.55 [1.42, 1.69]

Diabetes mellitus

996

160,801

6.2

2.35 [2.20, 2.51]

414

136,882

3.02

2.95 [2.67, 3.27]

Chronic hypertension

423

44,759

9.5

3.52 [3.19, 3.88]

126

35,036

3.60

3.35 [2.81, 4.01]

Congenital anomaly

832

61,034

13.6

5.26 [4.90, 5.65]

346

50,707

6.82

6.71 [6.01, 7.50]

Male sex

7130

2,200,877

3.2

1.42 [1.37, 1.47]

2739

1,994,128

1.37

1.70 [1.59, 1.81]

All

11,942

4,302,444

2.8

-

4292

3,910,864

1.10

-

  1. aRates of RDS <32 weeks represent cumulative incidence from 24 to 31 weeks (8 week period) and cannot be directly compared with rates of RDS ≥39 weeks which represent cumulative incidence from 39 to 43 weeks (5 week period)
  2. bOdds ratios were estimated by contrasting the RDS rate among those with and those without the risk factor e.g., RDS < 32 weeks among infants of smokers vs nonsmokers. Since odds ratios express the relative effect of risk factors on RDS, the odds ratios for early gestation RDS can be directly compared with the odds ratios for late gestation RDS