14-16 Weeks Gestation | 26-28 Weeks Gestation | 35-37 Weeks Gestation | Birth | 3-7 Days After Birth | Infant Age 3 Months | Infant Age 6 Months | Infant Age 12 Months | ||
---|---|---|---|---|---|---|---|---|---|
Intervention: new bottle study capsules | ✓ Intervention commences | ✓ | ✓ | ✓ | Intervention stops | ||||
Questionnaire | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
Objective measures and samples: Maternal | |||||||||
Vaginal swab (BV) | ✓ | ✓ | |||||||
Vagino-rectal swab (GBS) | ✓ | ✓ | |||||||
Anthropometrya,b,c,d | ✓ | ✓ | ✓ | ✓ | |||||
Blood samples (OGTT and serum) | ✓e | ||||||||
Faecal sample | ✓ | ||||||||
3 day food diary | ✓ | ||||||||
Cord blood and tissue | ✓ | ||||||||
Breast milk | ✓ | ||||||||
Skin prick test | ✓Completed after birth | ||||||||
Objective measures and samples: Infant | |||||||||
Anthropometrya,b,c | ✓ | ✓ | ✓ | ||||||
Eczema | ✓ | ✓ | |||||||
SCORAD | ✓ | ✓ | |||||||
Faecal sample | ✓ | ||||||||
48 hour food diary | ✓ | ||||||||
Buccal sample | ✓ | ||||||||
Skin swabs | ✓ | ||||||||
Skin prick test | ✓ | ||||||||
Objective measures and samples: Paternal | |||||||||
Anthropometrya,b,c | ✓Completed at any visit after birth | ||||||||
Skin prick test | ✓Completed at any visit after birth |