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Fig. 4 | BMC Pregnancy and Childbirth

Fig. 4

From: Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fig. 4

Effect of statins on heme-oxygenase 1 mRNA expression. a Simvastatin (0, 5 μM), rosuvastatin (0, 5 μM) and Pravastatin (0, 200 μM) up-regulated heme-oxygenase 1 expression by HUVECs. b Simvastatin 100 μM up-regulated heme-oxygenase 1 in preeclamptic placental explants, whist pravastatin 2000 μM and rosuvastatin 100 μM had no significant effect. Data represents n = 3–4 separate experiments and is expressed as mean ± SEM. Dark blue bars = control, light blue bars = statin treatments. a = p < 0.05, c = p < 0.001, d = p < 0.0001

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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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