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Table 2 Mortality in trials of IVIG for proven infection in neonates

From: The INIS Study. International Neonatal Immunotherapy Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial

Study

Exptl n/N

Ctrl n/N

Relative Risk (95% CI Fixed)

Weight

Chen 1996

2/28

1/28

2.00 [0.19, 20.82]

3.8%

Erdem 1993

5/15

7/16

0.76 [0.31, 1.89]

25.4%

Haque 1988

1/21

4/23

0.27 [0.03, 2.26]

14.3%

Mancilla-Ramirez 1992

2/19

2/18

0.95 [0.15, 6.03]

7.7%

Samatha 1997

0/12

4/16

0.15 [0.01, 2.46]

14.6%

Sidiropoulos 1981

2/20

4/15

0.38 [0.08, 1.78]

17.2%

Weisman 1992

2/14

5/17

0.49 [0.11, 2.13]

17.0%

Total

14/129

27/133

0.55 [0.31, 0.98]

100%

  1. Review: IVIG in neonatal infection
  2. Comparison: IVIG vs placebo or no intervention for proven infection
  3. Outcome: Mortality from any cause
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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