Table 2 Subgroup analyses of accuracy of biochemical screening to predict small for gestational age and pre-eclampsia (random effects pooling)

AFP>2.0MoM (BW<10th centile)

Incidence

>10%

2.69 (1.36–5.31)

0.98 (0.96–1.00)

0.04 (0.02–0.08)

0.98 (0.98–0.99)

≤ 10%

3.71 (2.66–5.16)

0.93 (0.88–0.97)

0.06 (0.05–0.07)

0.98 (0.98–0.98)

HCG>2.0MoM(BW<10th centile)

Incidence

>10%

1.53 (1.1–2.12)

0.89 (0.77–1.04)

0.29 (0.22–0.37)

0.79 (0.77–0.82)

≤ 10%

1.92 (1.72–2.13)

0.95 (0.94–0.96)

0.11 (0.1–0.12)

0.94 (0.94–0.95)

AFP>2.0MoM

Incidence

>4%

0.85 (0.41–1.78)

1.01 (0.97–1.06)

0.06 (0.02–0.13)

0.93 (0.91–0.94)

≤ 4%

2.98 (1.77–5.03)

0.96 (0.95–0.97)

0.08 (0.06–0.09)

0.96 (0.96–0.96)

HCG>2.0MoM

Incidence

>4%

2.45 (0.65–2.93)

0.68 (0.42–1.1)

0.25 (0.21–0.3)

0.92 (0.91–0.93)

≤ 4%

2.36 (1.81–3.08)

0.89 (0.85–0.95)

0.18 (0.16–0.2)

0.93 (0.92–0.93)