From: Cyclic AMP signalling pathways in the regulation of uterine relaxation
Physiological roles (see Shabb (2001) [38]) | Protein substrate (HUGO nomenclature) | References |
---|---|---|
Autophosphorylation | cAMP dependant protein kinase regulatory subunit type IIα (PRKAR2A) | Zakhary et al. (2000) [39] |
cAMP signalling | β-2 adrenoceptor (ADRB2) | Daaka Y et al. (1997) [40]; Iyer et al. (2006) [41] |
G protein coupled receptor kinase-2 (ADRBK1) | Houslay & Baillie (2006) [42] | |
Phosphodiesterase 4 (PDE4) | Murthy et al. (2002) [43] | |
Phosphoinositide and calcium signalling | InsP3 Type I receptor (ITPR1) | Straub et al. (2004) [44] |
Phospholipase-C β3 (PLCB3) | Yue et al. (1998) [45] | |
Phospholipase-C γ1 (PLCG1) | Park et al. (1992) [46] | |
ATPase 2 (ATP2) | Tribe et al. (2000) [47] | |
Regulators of G-protein signalling (RGS) | Suarez et al. (2003) [48] | |
Thromboxane A2 receptor (TBXA1R) | Walsh et al. (2000) [49] | |
Rho signalling | RhoA small GTP binding protein (RHOA) | Murthy et al. (2003) [50] |
Gα13 | Manganello et al. (2003) [51] | |
Smooth muscle contraction | Myosin light chain kinase (MYLK) | Hirano et al. (2004) [52] |
Myosin binding subunit of myosin phosphatase (PPP1R12A) | Wooldridge et al. (2004) [53] |