Characteristic | Phase I | Phase II | P value ‡ |
---|---|---|---|
Total participants (n) | 202 | 186 | Â |
   Serum folate (nmol/L) | 14.8 (14.0 – 15.6) | 23.0 (22.0 – 24.1) | <0.001 |
   RBC folate (mol/L) | 745 (713 – 779) | 916 (873 – 961)†| <0.001 |
   Plasma HCY (μmol/L) | 13.6 (13.0 – 14.2)†| 12.3 (11.7 – 12.9)†| 0.001 |
   Serum vitamin B12 (pmol/L) | 183 (173 – 194) | 216 (202 – 231) | <0.001 |
   Plasma MMA (μmol/L) | 0.24 (0.22 – 0.27)†| 0.26 (0.24 – 0.28) | 0.229 |