Table 1 Detection of Trisomy 21 with fixed false positive rates
From: The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy
Markers | AUCDF | 5% FPR | 10%FPR |
|---|---|---|---|
βhCG + PAPPA | 0.918 | 0.49(0.27 – 0.73) | 0.73(0.55 – 0.92) |
PAPPA + NT | 0.922 | 0.66(0.5 – 0.81) | 0.78(0.64 – 0.9) |
PAPPA + hCG-sLHCGR | 0.92 | 0.81(0.68 – 0.91) | 0.84(0.74 – 0.95) |
βhCG + hCG-sLHCGR | 0.856 | 0.53(0.39 – 0.75) | 0.65(0.5 – 0.83) |
βhCG + NT | 0.753 | 0.23(0.11 – 0.37) | 0.36(0.23 – 0.51) |
hCG-sLHCGR + NT | 0.888 | 0.71(0.56 – 0.84) | 0.77(0.63 – 0.88) |
NT + PAPPA + βhCG | 0.94 | 0.59(0.35 – 0.83) | 0.83(0.66 – 0.97) |
NT + PAPPA + hCG-sLHCGR | 0.928 | 0.84(0.72 – 0.95) | 0.87(0.76 – 0.98) |
hCG-sLHCGR + NT + PAPPA + βhCG | 0.966 | 0.83(0.73 – 0.92) | 0.9(0.82 – 0.97) |