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Table 1 Studies evaluating central aortic pressures on pregnancy associated hypertensive disorders

From: A cohort evaluation on arterial stiffness and hypertensive disorders in pregnancy

ID

Author year/country published

Study design/sample size

Study population (Stage of pregnancy)

Measures of arterial stiffness

Normal pregnancy group

Pre-eclampsia group

P Value (Crude analysis)

1

Khalil [10] 2008 United Kingdom

Cohort 218

11–13 + 6 weeks of amenorrhea

AI

AI-OR1(Referent)

AI-§ Odds Ratio 21.3 (95% CI5.5-82.3)

<0.001

2

Robb [15] 2010 United Kingdom

Cohort 47

At 16 weeks of amenorrhea/after PE diagnosis

CAPP

CAPP-Mean 26 (SD1) mmHg

CAPP- Mean 37 (SD2) mmHg

<0.0001

3

Spasojevic [8] 2005 Australia

Cohort 99

24-39 weeks of amenorrhea

AI

AI-Mean 0.3(SD7.4)%

AI-Mean 24.2(SD8.1)%

<0.0001

4

Khalil [9] 2009 United Kingdom

Nested case control 252

11 – 13 + 6 weeks of amenorrhea

AI

AI-Ç‚ MOM 0.8 (IQR0.5-1.2)%

AI-Ç‚ MOM 1.5 (IQR1.3-1.8)%

<0.002

5

Avni [14] 2010 United States of America

Cross-sectional 100

Any pregnancy gestation

AI

AI-Mean 12.3 (SD7.4)%

AI-Mean 32.4 (SD7.5)%

0.001

6

Kaihura [16] 2009 United Kingdom

Cross-sectional 123

Any pregnancy gestation

CAPP & AI

CAPP-Median 27 (IQR24.2-31.5) mmHg

CAPP-Median 43.5 (IQR37.7-47.8) mmHg

<0.0001

AI-Mean 4 (SD13.6)%

AI-Mean 25.1 (SD11.2)%

<0.0001

7

Ronnback [17] 2005 Finland

Cross-sectional 96

30-42 weeks of amenorrhea

CAPP & AI

CPP-Mean 29 (Range 23-45) mmHg

CPP- Mean 39 (Range 28-65) mmHg

<0.001

AI-Mean 4 (SD1)%

AI-Mean 23 (SD2)%

<0.001

8

Taspinar [18] 2004 Netherlands

Cross-sectional 122

Third Trimester

CAPP & AI

CPP-Mean 28 (SD5) mmHg

CPP- Mean 44 (SD17) mmHg

<0.05

     

AI-Mean 6.7 (SD14)%

AI-Mean 31.1 (SD12.4)%

<0.05

  1. CAPP = Central Aortic Pulse Pressure in mmHg, AI = Augmentation Index in%,
  2. * = Median (Interquartile range).
  3. Ç‚ = Multiples of Median(Interquartile range).
  4. § = Odds Ratio(95% confidence interval).