Communities, birth attendants and health facilities: a continuum of emergency maternal and newborn care (the global network's EmONC trial)
- Omrana Pasha1Email author,
- Robert L Goldenberg2,
- Elizabeth M McClure3,
- Sarah Saleem1,
- Shivaprasad S Goudar4,
- Fernando Althabe5,
- Archana Patel6,
- Fabian Esamai7,
- Ana Garces8,
- Elwyn Chomba9,
- Manolo Mazariegos10,
- Bhala Kodkany4,
- Jose M Belizan5,
- Richard J Derman11,
- Patricia L Hibberd12,
- Waldemar A Carlo13,
- Edward A Liechty14,
- K Michael Michael Hambidge15,
- Pierre Buekens16,
- Dennis Wallace3,
- Lisa Howard-Grabman17,
- Suzanne Stalls18,
- Marion Koso-Thomas19,
- Alan H Jobe20 and
- Linda L Wright19
© Pasha et al; licensee BioMed Central Ltd. 2010
Received: 31 August 2010
Accepted: 14 December 2010
Published: 14 December 2010
Maternal and newborn mortality rates remain unacceptably high, especially where the majority of births occur in home settings or in facilities with inadequate resources. The introduction of emergency obstetric and newborn care services has been proposed by several organizations in order to improve pregnancy outcomes. However, the effectiveness of emergency obstetric and neonatal care services has never been proven. Also unproven is the effectiveness of community mobilization and community birth attendant training to improve pregnancy outcomes.
We have developed a cluster-randomized controlled trial to evaluate the impact of a comprehensive intervention of community mobilization, birth attendant training and improvement of quality of care in health facilities on perinatal mortality in low and middle-income countries where the majority of births take place in homes or first level care facilities. This trial will take place in 106 clusters (300-500 deliveries per year each) across 7 sites of the Global Network for Women's and Children's Health Research in Argentina, Guatemala, India, Kenya, Pakistan and Zambia. The trial intervention has three key elements, community mobilization, home-based life saving skills for communities and birth attendants, and training of providers at obstetric facilities to improve quality of care. The primary outcome of the trial is perinatal mortality. Secondary outcomes include rates of stillbirth, 7-day neonatal mortality, maternal death or severe morbidity (including obstetric fistula, eclampsia and obstetrical sepsis) and 28-day neonatal mortality.
In this trial, we are evaluating a combination of interventions including community mobilization and facility training in an attempt to improve pregnancy outcomes. If successful, the results of this trial will provide important information for policy makers and clinicians as they attempt to improve delivery services for pregnant women and newborns in low-income countries.
Research justification and relevant literature
More than half a million maternal deaths, over 3 million stillbirths and 3 million early neonatal deaths occur each year worldwide, the majority in South Asia and sub-Saharan Africa[1–4]. Delivery complications (prolonged labor, preeclampsia, maternal infection and obstetric hemorrhage) are responsible for half of all maternal deaths, one-third of stillbirths and one-quarter of neonatal deaths [5–9]. Intrapartum complications are also responsible for maternal morbidity, e.g., hemorrhage and obstetric fistulae, as well as childhood disability and long-term impairment [10–12]. Pregnancy complications, which are not easily predicted, usually first become apparent during labor and often require timely facility-based management to avert death and severe morbidity .
Emergency Obstetric and Neonatal Care (EmONC) requires a skilled birth attendant with the ability to provide parenteral medications (e.g., antibiotics, oxytocics, anticonvulsants); carry out procedures (e.g., manual removal of the placenta, forceps/vacuum deliveries); perform blood transfusions, cesarean sections and provide newborn care/resuscitation . Despite established interventions, the majority of maternal and neonatal deaths occur due to a lack of access to life-saving services [15, 16]. Women most likely to experience obstetrical emergencies are those with least access to appropriate services [17, 18]. The medical model of maternal/newborn survival, with a linear path between recognition of intrapartum complications, stabilization/referral and receipt of good quality care, is complicated by contextual and cultural factors which may pose intractable barriers to access .
Current efforts to reduce peripartum deaths focus on skilled delivery attendance for every birth backed up by emergency obstetric care and facility-based delivery [19, 20]. However, 60 million births currently occur outside facilities, 52 million without skilled attendance . It is unlikely that countries with the majority of these deliveries will be able to establish systems to implement wide-scale skilled birth attendance in the near future. Equally doubtful is their ability to accommodate a large-scale shift in delivery site to facilities providing comprehensive delivery care in the near future . Reducing peripartum morbidity and mortality will require solutions that take into account the scarce resources and inadequate infrastructure in countries with the worst indicators.
Substantive evidence for the reduction of intrapartum deaths focuses on individual interventions: pharmacologic management, community-participatory approaches, and health system interventions [15, 16, 23]. The problem does not appear to be lack of innovation but of appropriate, sustainable provision of these services to those who need them most . Programs have used various combinations of these interventions successfully [13, 22, 25, 26]; however, these combined programs have not been scientifically evaluated to determine whether they are effective in reducing intrapartum deaths.
A continuum of services to reduce delays in emergency obstetric and newborn care
A successful model for reduction of intrapartum mortality must span care across time and place, including families, communities and providers of delivery and related services, with an emphasis on coverage and quality of care as well as functional linkages between the various levels of care .
The Alma Ata declaration reaffirmed the goal of "Health for All" and identified primary health care as the key to attaining this goal . The declaration was based on the premise that, within communities, individuals and groups had to be part of the planning, implementation and appraisal efforts to meet their own needs on a sustained basis . The emphasis on multi-sector and community involvement was lost as a selective model of primary health care was implemented . Thirty years later, despite gains in many health outcomes, deaths around the time of delivery have proven to be difficult to reduce. There is increasing recognition that broad ownership of health and health systems may be one of the keys to improving peripartum outcomes.
Existing health systems, as service providers and regulators, are major stakeholders for improving maternal newborn health (MNH). Programs to bring about sustained change in MNH outcomes should reinforce national commitment . Countries that have prioritized MNH at a national level, e.g. Rwanda and Nepal, have made major strides despite substantial challenges [32–34].
Successful community participatory approaches have shown reductions in maternal/neonatal mortality in Bolivia, India, Bangladesh and Nepal and provide evidence for engaging another key stakeholder, the community [35–39]. A range of approaches has been described as community mobilization/participation and can be differentiated on the actual level of community involvement. Community ownership and capacity to act independently increase the likelihood of sustained change . A promising approach is one that builds on inherent community resources; this model has the advantage of being self-sustaining [41, 42]; improving outcomes by capitalizing on existing community strengths and focusing on resources that can be leveraged to improve health . Existing skills and resources which lead to better outcomes can be ascertained by identifying individuals who have solved problems despite being at greatest risk of a bad outcome .
Deliveries at home and primary facilities
Changing the behavior of families and communities during pregnancy, delivery and post-partum and reducing demand-side barriers to health service by addressing context-specific delays can improve outcomes in populations where the majority of deliveries take place at home or in primary facilities [15, 45, 46].
Interventions that have been proven effective or have strong conceptual underpinnings include improvements in domiciliary delivery practices such as hand-washing, use of a clean home delivery kits and/or clean blade to cut the cord ; birth preparedness, e.g. availability of funds, transport mechanisms and comprehensive obstetric care facilities; and early recognition of and appropriate responses to complications[22, 48]. Traditional birth attendants (TBA's) remain the main provider of delivery care especially in settings where mortality rates are high . Despite the lack of evidence supporting TBA training as a single intervention, there are data to support the inclusion of trained TBA's within an improved health care system [16, 49–51].
Quality of emergency obstetric and newborn care
Ideally, best practices based on current international standards should be available to all women presenting with obstetrical emergencies [12, 52]. EmONC packages which include intrapartum monitoring may improve newborn survival (neonatal mortality reduction 25-75%) and reduce maternal mortality [24, 52, 53]. The challenge in settings with the worst intrapartum outcomes is to appropriately implement EmONC packages. Efforts to improve quality of care have focused on training including in-service training and obstetric simulations and drills [54, 55]. Another effective tool for improving quality of care is the use of perinatal audits to institute changes or solutions for problems that caused fatality, with each cycle building on the previous one .
Study rationale and objectives
An underlying premise of this study is that EmONC teams consisting of local residents and health care providers can develop and implement comprehensive interventions to address limited access to quality emergency obstetric and neonatal care. The EmONC trial will test the hypothesis that implementing these locally-driven processes can lead to a substantial reduction in poor perinatal outcomes in intervention compared to control locations with standard care. These EmONC teams will work within their community and with the existing health care system to reduce adverse pregnancy outcomes through a broad intervention which includes community mobilization to strengthen community capacity to identify and address barriers to improved MNH and drive client-oriented emergency obstetrical and neonatal care; community-based training to recognize prolonged labor, infection, preeclampsia and hemorrhage, and the use of appropriate stabilization methods that can be employed in homes and in first level care facilities; and improvement of quality of care in existing health facilities.
This community-based, two-arm cluster-randomized controlled trial will evaluate the impact of an EmONC package introduced by EmONC cluster teams in intervention clusters compared to standard care in control clusters. The study includes 106 clusters (defined as distinct geographic areas with approximately 300-500 births per year) and encompasses all deliveries therein. All clusters have pre-existing independent maternal-newborn health registry systems, i.e. independent, prospective, population-based active surveillance mechanisms to assess rates of stillbirth, neonatal and maternal mortality, on which the outcome assessment will be based.
The primary outcome of the study is perinatal mortality, defined as the composite rate of stillbirth and 7-day neonatal mortality per 1000 births. We will collect outcome data on all births at 20 weeks gestation and greater, but the primary outcome will include events for those pregnancies that occur at ≥28 weeks or ≥1000 g. Secondary outcomes will include stillbirths, 7-day neonatal mortality, maternal death or severe morbidity (including obstetric fistula, eclampsia and obstetrical sepsis) and 28-day neonatal mortality. Other outcomes of interest include rates of transport to hospital of both mothers and newborns.
Enrollment - Trial sites
EmONC trial study sites
Total deliveries (n)a
Home deliveriesa (%)
Interventions in intervention sites
The intervention is based on best practices from existing research and programmatic experience by the GN's EmONC Trial investigators, comprised of obstetricians, neonatologists and public health professionals well versed in and/or practicing MNH in low-resource settings. All activities detailed below are implemented throughout the intervention areas.
EmONC teams' goals
Work in partnership with the local health authorities.
Implement an organized process of community mobilization, and social and behavioral change based on a "Community Action Cycle" that strengthens communities' capacity to organize, explore MNH issues and set priorities, plan, implement, monitor, evaluate and share effective strategies and systems that increasingly improve EmONC care and MNH outcomes.
Analyze preventable causes of peripartum mortality and existing community resources for EmONC, including quality evaluation of the MNH care services.
Assist communities to identify and leverage available resources to address barriers to EmONC (e.g., communications and transport for EmONC).
Identify and assess capacity of available EmONC referral hospitals, work with hospital staff to accept transfers, perform appropriate cesarean sections/other procedures and review/maintain quality of care. Actively engage community members as advocates for improvement in quality of care.
Identify/train all community birth attendants/health workers, as appropriate, to (a) identify need for referral for severe maternal/newborn illnesses (b) facilitate transfer to an EmONC facility by identifying and arranging for locally available and sustainable methods of transportation (c) stabilize the woman/newborn prior to/during transport () communicate with hospital staff for timely and effective transport.
Establish a quality assurance review in each cluster to review each maternal, fetal or neonatal death to determine if it was preventable and how to prevent similar deaths in the future.
EmONC team tools
To accomplish the components of the intervention described above, master trainers will facilitate central and regional training of 1 to 2 Country trainers in each of the following areas: (1) community mobilization; (2) birth attendant training, and (3) EmONC referral facility improvement.
Sustainable community mobilization must move beyond raising community awareness about an issue or persuade people to engage in predetermined activities. The Community Action Cycle (CAC), a comprehensive strategy, empowers communities to take charge of problems within their own context. The CAC has seven key phases: 1) Prepare to mobilize - the methodology to work with communities is designed, the study teams are established and trained, and they identify and train community facilitators; 2) Organize the community for action- the team enters the community, establishes credibility; raises community awareness about MNH; and works with communities to identify and invite those most likely to be affected by and interested in MNH issues to organize "core groups"; 3) Explore MNH issues and set priorities -core group members explore MNH problems and existing practices in their core groups and with the broader community and set priorities based on what they learn; 4) Plan together- core group members engage in a planning process with community leaders and resource people including health providers to develop a Community Action Plan and establish coordinating and monitoring mechanisms; 5) Act together - the community implements their plan and monitors progress, adjusting course as necessary; 6) Evaluate together- the community evaluates results, shares what it has learned, and prepares to begin the cycle again; 7) Prepare to scale-up - the community and/or the program team expands the approach to other communities.
Individuals from outside the community must establish relationships with communities built on mutual respect and allow the community to solve their problems in the most contextually appropriate way. The CAC works well with HBLSS as well as with efforts to strengthen of facility-based services.
Birth Attendant Training
Home Based Life Saving Skills (HBLSS), developed by the American College of Nurse Midwives, is a family/community-based program to reduce maternal/neonatal mortality with emphasis on basic life saving care at the community level; reduction in delays in reaching facilities and supporting birth preparedness involving key decision makers. HBLSS is a competency-based training intervention for community women and men, focusing on practices that are safe, feasible and acceptable to the community. HBLSS emphasizes community involvement during the administration of a 12-item curriculum of preventive/life saving skills. The pictorial HBLSS 'Take Action' cards are particularly useful in communities with low literacy levels. The core curriculum is complemented by activities to develop emergency transportation systems and involve community leaders, particularly men . We emphasize that the entire community, including traditional birth attendants, received HBLSS training.
Improvement in Quality of Care at Facilities
The facility training utilized curriculum adapted from Jhpiego which includes a training curriculum and practice sessions in the following areas: emergency preparedness, essential newborn care, obstetrical care. The curriculum includes training on drills aimed at improving facility responses to emergency conditions such as hemorrhage and eclampsia, which are then to be conducted in-country, as are regularly occurring audits for all maternal, fetal and neonatal deaths. The site facility trainer is expected to visit each EMONC facility to conduct assessments of the facility each 6 months, and hold training sessions aimed at improving maternity and newborn care on a regular basis.
EmONC team intervention and implementation
All the teams underwent a central, intensive two-week training of trainers (TOT) led by Master Trainers. Separate trainers were identified for each site to work in three major areas: EmONC Facility Improvement, HBLSS training and Community Mobilization. The TOT was followed by one week in-country training led by Country Trainers for key stakeholders and supported by Master Trainers at each site. Each team was provided all relevant materials for the CAC, HBLSS curriculum and the facility improvement methodology, as well as a common manual of operations for field implementation. Each team utilized the tools in the most contextually appropriate method for their site in order to achieve the study objectives.
Interventions in control clusters
The Maternal Newborn Health (MNH) registry detailed below is the only study-related activity in the control clusters.
Administrative Structures - The Global Network's Subcommittee for the EmONC Trial
Administrative Structures - The EmONC Trial Country Team
At each site, the senior in-country investigators work with key members of the team responsible for implementation of the intervention and for the process data collection, including:
EmONC Country Coordinator: responsible for overseeing the conduct of the study
Community Mobilization Trainer: responsible for the training of Community Mobilization facilitators
Birth Attendant Trainer: responsible for birth attendant training
EmONC Facility/Skilled Birth attendant Trainer: physician responsible for leading the quality improvement and training at the EmONC facilities and leading the training for the skilled birth attendants at the level one health clinics.
Administrative Structures - The EmONC Country Advisory Group
Each Country Team is supported by an EmONC Country Advisory Group consisting of the senior in-country investigator, EmONC Country Coordinator, a senior physician from a referral facility, three country trainers, a government health official, a community representative, a maternal representative and a birth attendant representative. The Advisory Groups facilitate buy-in for the intervention, assist in organizing trainings, death audits and community-based activities.
Administrative Structures - EmONC Cluster Teams
The Cluster Teams are led by Cluster Coordinators and are responsible to oversee and coordinate all community mobilization activities and HBLSS training in their respective clusters. The EmONC Cluster Teams at each site meet once a month with the Country Team to discuss progress and obstacles in the implementation of the trial.
Administrative Structures - Community (Village) Committees
These committees are formed through the CAC and are comprised of active community members who are responsible for coordinating implementation of the community's plan (e.g., improving transport, maintaining emergency funds, carrying out death audits, etc.) and monitoring results.
Administrative Structures - The Data Coordinating Center
RTI International is the DCC for this trial. They are responsible for maintaining the central study database. In addition, they also generate descriptive statistics to monitor enrollment and retention, as well as process indicators for implementation of the study intervention.
Informed Consent and Research Ethics
The study protocol and informed consent documents were reviewed and approved by the institutional review boards at all participating sites in as well as at the partner U.S. sites and DCC.
Informed consent was sought at two levels
Community and Health Facility Consent: Agreement for study participation was sought from all participating communities and facilities in advance of randomization. Responsible community health authorities agreed to participate before beginning any activities. Communities were informed of their assignment to the control or intervention arm following randomization.
Pregnant women and their offspring: Informed consent for data collection is sought from all pregnant women that are residents of or deliver within the study clusters.
The primary publication for the trial will follow CONSORT guidelines for randomized controlled trials. Criteria for authorship of all papers, presentations, and reports resulting from the study will conform to ICMJE standards.
Multiple mechanisms are in place to assure the fidelity of the intervention and the quality of data collection. Cluster Coordinators, selected by the EmONC Country Team based on their skills, received training and certification on data collection, with refresher training conducted as needed. Cluster Coordinators directly monitor all aspects of the study intervention. The Country Team members visit the participating communities routinely. The DCC performs inter and intra-form edits to assure data consistency and monitors double-data entry. In addition, the DCC statisticians perform data quality reviews on an ongoing basis.
Data Monitoring Committee, Interim Analyses and Stopping Rule
The NICHD-designated Data Monitoring Committee (DMC) reviews the data including enrollment, compliance, protocol violations, outcomes, and adverse events, at least every six months. Adverse events (including death, life-threatening events, and hospitalization) are monitored by onsite staff, submitted to the DCC and reported to the DMC.
Statistical Design and Sample Size
The cluster-randomized trial was designed to test the impact of the intervention on perinatal mortality with the cluster as the unit of randomization and analysis. We will test the primary hypothesis that the EmONC will reduce the risk of perinatal mortality (measured as the total number of stillbirths and 7-day neonatal deaths per 1000 deliveries) with a permutation test conducted at the cluster level. Secondary analyses of this same hypothesis controlling for individual-level covariates will be conducted using extensions of the generalized linear model that account for the correlation within cluster. An assessment of whether the 106 possible clusters available provided adequate power to test this hypothesis was conducted under the assumptions that on average the clusters will contribute 300 to 500 deliveries per year with a base mean rate of perinatal death of 40 to 50 per 1,000 deliveries and an intra-class correlation coefficient between 0.005 and 0.01 (based on preliminary data collected from these clusters). Using a two-sided hypothesis test at the 5% level of significance, these 106 clusters will provide a power of at least 80% across the full range of assumptions and greater than 90% across much of the range to detect a reduction of 30% in the perinatal mortality.
Enrollment - Inclusion Criteria
The clusters have at least 300 deliveries per year with a minimum of 50% occurring at home or first level facilities. This is an intent-to-treat design. Thus all pregnancy outcomes of women who deliver in the study clusters and provide consent are collected.
Enrollment - Exclusion Criteria
The intervention is intended to work by improving knowledge and affecting behavior change throughout pregnancy. Improved outcomes at delivery will depend on accrued benefits. Women who first move into the study area within 4 weeks of their actual delivery date are unlikely to derive adequate benefit from the intervention and will be excluded from the primary outcome.
Preliminary data collected by the GN from these 106 clusters formed the basis for randomization. The DCC stratified clusters based on a cross-classification of birth and perinatal mortality rates and randomized within one to three comparable strata to intervention or control cluster within each Global Network site.
Enrolment - Enlisting participants in the trial
The MNH Registry is an ongoing population-based pregnancy outcome data collection program in each of the clusters in the GN's 7 trial sites. The MNH Registry tracks all pregnancies, deliveries and delivery outcomes with its own staff which functions independently from the EMONC trial staff in order to reduce bias due to joint outcome data collection. The Registry in each cluster is managed by a Registry Administrator who, with assistants as needed, screens, enrolls, and tracks all pregnant women within the clusters. They obtain consent for data collection during pregnancy and collect delivery outcomes from all known pregnancies and all deaths of pregnant women up to and including 42 days post delivery/pregnancy termination, and 28-day neonatal outcomes. The Registry collects data during three visits to each mother including an enrollment visit as early as possible within pregnancy (targeted for 20 weeks gestation or greater), a second visit within 48 hours of delivery and a visit at day 42 after birth.
Data Collection and Management
Outcome and process data are collected separately for the trial. Outcome data are collected through the MNH Registry utilizing standardized instruments to measure maternal demographic data, health care utilization, MNH outcomes and serious adverse events. Data collected for the EmONC trial implementation are collected using standardized instruments in the intervention clusters; process data include cluster team activities, community mobilization activities and training logs. Facility and community-based death audit forms support the activities of the facility trainers and community mobilization teams that utilize them for teaching and discussion.
All data are collected prospectively in the local language using hard copy forms, with only the individual study identification number on each form in order to maintain confidentiality. The forms are keyed into computers at in each country using a common data management system. At intervals ranging from daily to once per week, data are transmitted to the DCC for inclusion in the central database. The hard copy forms are retained in-country in a secure location.
Perinatal mortality and morbidity remains one of the largest challenges for improving maternal and child health in low and middle-income countries. Despite a good understanding of health interventions that can reduce this burden, sustained implementation has been a challenge. A comprehensive package of interventions spanning the continuum of care from the home to the hospital, with a robust community mobilization component, has the potential to significantly improve both maternal and fetal/newborn outcomes. The findings from the current RCT therefore may inform health policy for interventions that are scalable and sustainable in a variety of settings in LMIC.
EMONC Trial Group of the Global Network for Women's and Children's Health Research: Argentina - Fernando Althabe, Jose M. Belizan, and Claudio Sosa (Institute for Clinical Effectiveness and Health Policy); Guatemala - Ana Garces, (San Carlos University); India - Shivaprasad S. Goudar and Bhalchandra S. Kodkany, (Jawaharlal Nehru Medical College), Archana Patel (Indira Gandhi Government Medical College); Pakistan - Sarah Saleem, Omrana Pasha (Aga Khan University); Christine Kaseba, Elwyn Chomba (University of Zambia) Peter Gisore, Hillary Mabaye, Fabian Esamai (Moi University); U.S.- Waldemar A. Carlo, (University of Alabama at Birmingham); Nancy Krebs and K. Michael Hambidge, (University of Colorado); Robert L. Goldenberg, (Drexel University); Richard J. Derman, (Christiana Healthcare, Delaware); Pierre Buekens, (Tulane School of Public Health and Tropical Medicine); Patricia Hibberd (Massachusetts General Hospital); Edward Liechty, (Indiana University); Linda L. Wright and Marion Koso-Thomas (Eunice Kennedy Shriver National Institute of Child Health and Human Development); Janet Moore, Dennis Wallace, and Elizabeth M. McClure (Research Triangle International).
This project is funded by grants from the Eunice Kennedy Shriver National Institute on Child Health and Human Development.
- Ronsmans C, Graham WJ: Lancet Maternal Survival Series steering group. Maternal mortality: who, when, where, and why. Lancet. 2006, 368: 1189-200. 10.1016/S0140-6736(06)69380-X.View ArticlePubMedGoogle Scholar
- Stanton C, Lawn JE, Rahman H, Wilczynska-Ketende K, Hill K: Stillbirth rates: delivering estimates in 190 countries. Lancet. 2006, 367: 1487-94. 10.1016/S0140-6736(06)68586-3.View ArticlePubMedGoogle Scholar
- Lawn JE, Cousens S, Zupan J: Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: When? Where? Why?. Lancet. 2005, 365: 891-900. 10.1016/S0140-6736(05)71048-5.View ArticlePubMedGoogle Scholar
- Hyder AA, Wali SA, McGuckin J: The burden of disease from neonatal mortality: a review of South Asia and Sub-Saharan Africa. BJOG. 2003, 110: 894-901. 10.1111/j.1471-0528.2003.02446.x.View ArticlePubMedGoogle Scholar
- McClure EM, Goldenberg RL, Bann CM: Maternal mortality, stillbirth and measures of obstetric care in developing and developed countries. Int J Gynaecol Obstet. 2007, 96: 139-46. 10.1016/j.ijgo.2006.10.010.View ArticlePubMedGoogle Scholar
- World Health Organization: Perinatal mortality: a listing of available information. FRH/MSM.96.7. 1996, Geneva: WHOGoogle Scholar
- National Health Survey of Pakistan: Health profile of the people of Pakistan. Islamabad, Pakistan: Pakistan Medical Research Council. 1998Google Scholar
- Sibley LM, Sipe TA, Brown CM, Diallo MM, McKatt K, Habarta N: Traditional birth attendant training for improving health behaviors and pregnancy outcomes (review). Cochrane Database of Systematic Review. 2007, CD005460-Google Scholar
- Lawn J, Shibuya K, Stein C: No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ. 2005, 83: 409-17.PubMedPubMed CentralGoogle Scholar
- Ronsmans C: Severe acute maternal morbidity in low income countries. Best Pract Res Clin Obstet Gynaecol. 2009, 23: 305-16. 10.1016/j.bpobgyn.2009.01.001.View ArticlePubMedGoogle Scholar
- AbouZahr C: Global burden of maternal death and disability. Br Med Bull. 2003, 67: 1-11. 10.1093/bmb/ldg015.View ArticlePubMedGoogle Scholar
- Lawn JE, Kinney M, Lee AC, Chopra M, Donnay F, Paul VK, et al: Reducing intrapartum-related deaths and disability: Can the health system deliver?. Int J Gynaecol Obstet. 2009, 107 (Suppl 1): S123-40. 10.1016/j.ijgo.2009.07.021. S140-2.View ArticlePubMedGoogle Scholar
- Campbell OM, Graham WJ: Lancet Maternal Survival Series steering group. Strategies for reducing maternal mortality: getting on with what works. Lancet. 2006, 368: 1284-99. 10.1016/S0140-6736(06)69381-1.View ArticlePubMedGoogle Scholar
- Penny S, Murray SF: Training initiatives for essential obstetric care in developing countries: a 'state of the art' review. Health policy planning. 2000, 15: 386-93. 10.1093/heapol/15.4.386.View ArticlePubMedGoogle Scholar
- Manandhar DS, Osrin D, Shrestha BP, Mesko N, Morrison J, Tumbahangphe KM, et al: Members of the MIRA Makwanpur trial team. Effect of a participatory intervention with women's groups on birth outcomes in Nepal: cluster-randomised controlled trial. Lancet. 2004, 364: 970-9. 10.1016/S0140-6736(04)17021-9.View ArticlePubMedGoogle Scholar
- Jokhio AH, Winter HR, Cheng KK: An intervention involving traditional birth attendants and perinatal and maternal mortality in Pakistan. N Engl J Med. 2005, 352: 2091-9. 10.1056/NEJMsa042830.View ArticlePubMedGoogle Scholar
- Thaddeus S, Maine D: Too far to walk: maternal mortality in context. Soc Sci Med. 1994, 38: 1091-110. 10.1016/0277-9536(94)90226-7.View ArticlePubMedGoogle Scholar
- Gabrysch S, Campbell OM: Still too far to walk: Literature review of the determinants of delivery service use. BMC Pregnancy Childbirth. 2009, 9: 34-10.1186/1471-2393-9-34.View ArticlePubMedPubMed CentralGoogle Scholar
- Koblinsky M, Matthews Z, Hussein J, Mavalankar D, Mridha MK, Anwar I, et al: Lancet Maternal Survival Series steering group. Going to scale with professional skilled care. Lancet. 2006, 368: 1377-86. 10.1016/S0140-6736(06)69382-3.View ArticlePubMedGoogle Scholar
- Filippi V, Ronsmans C, Campbell OM, Graham WJ, Mills A, Borghi J, et al: Maternal health in poor countries: the broader context and a call for action. Lancet. 2006, 368: 2123-4.Google Scholar
- UNICEF: State of the World's Children 2009. 2009, New York: UNICEFGoogle Scholar
- Costello A, Azad K, Barnett S: An alternative strategy to reduce maternal mortality. Lancet. 2006, 368: 2122-3. 10.1016/S0140-6736(06)69388-4.View ArticleGoogle Scholar
- Derman RJ, Kodkany BS, Goudar SS, Geller SE, Naik VA, Bellad MB, et al: Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: a randomised controlled trial. Lancet. 2006, 368: 1248-53. 10.1016/S0140-6736(06)69522-6.View ArticlePubMedGoogle Scholar
- Paxton A, Maine D, Freedman L, Fry D, Lobis S: The evidence for emergency obstetric care. Int J Gynec Obstet. 2005, 88: 181-93. 10.1016/j.ijgo.2004.11.026.View ArticleGoogle Scholar
- Chowdhury ME, Ahmed A, Kalim N, Koblinsky M: Causes of maternal mortality decline in Matlab, Bangladesh. J Health Popul Nutr. 2009, 27: 108-23. 10.3329/jhpn.v27i2.3325.View ArticlePubMedPubMed CentralGoogle Scholar
- Lubbock LA, Stephenson RB: Utilization of maternal health care services in the department of Matagalpa, Nicaragua. Rev Panam Salud Publica. 2008, 24: 75-84. 10.1590/S1020-49892008000800001.View ArticlePubMedGoogle Scholar
- Kerber KJ, de Graft-Johnson JE, Bhutta ZA, Okong P, Starrs A, Lawn JE: Continuum of care for maternal, newborn, and child health: from slogan to service delivery. Lancet. 2007, 370: 1358-69. 10.1016/S0140-6736(07)61578-5.View ArticlePubMedGoogle Scholar
- Primary health care: Report of the International Conference on Primary Health Care, Alma-Ata, USSR, 6-12 September 1978, jointly sponsored by the World Health Organization and the United Nations Children's Fund. 1978, Geneva: World Health Organization, (Health for All Series, No. 1)Google Scholar
- Arole M, Arole R: Jamkhed, India--the evolution of a world training center. Just and lasting change: when communities own their futures. Edited by: Taylor-Ide D, Taylor CE. 2002, Baltimore: Johns Hopkins University Press, 150-60.Google Scholar
- Cueto M: The ORIGINS of primary health care and SELECTIVE primary health care. Am J Public Health. 2004, 94: 1864-74. 10.2105/AJPH.94.11.1864.View ArticlePubMedPubMed CentralGoogle Scholar
- Filippi V, Ronsmans C, Campbell OM, Graham WJ, Mills A, Borghi J, Koblinsky M, Osrin D: Maternal health in poor countries: the broader context and a call for action. Lancet. 2006, 368: 1535-41. 10.1016/S0140-6736(06)69384-7.View ArticlePubMedGoogle Scholar
- Logie DE, Rowson M, Ndagije F: Innovations in Rwanda's health system: looking to the future. Lancet. 2008, 372: 256-61. 10.1016/S0140-6736(08)60962-9.View ArticlePubMedGoogle Scholar
- Ensor T, Clapham S, Prasad PD: What drives health policy formulation: Insights from the Nepal Maternity Incentive Scheme?. Health Policy. 2008, 90: 247-53. 10.1016/j.healthpol.2008.06.009.View ArticlePubMedGoogle Scholar
- Tsai TC: Public health and peace building in Nepal. Lancet. 2009, 374: 515-6. 10.1016/S0140-6736(09)61473-2.View ArticlePubMedGoogle Scholar
- O'Rourke K, Howard-Grabman L, Seoane G: Impact of community organization of women on perinatal outcomes in rural Bolivia. Rev Panam Salud Publica. 1998, 3: 9-14. 10.1590/S1020-49891998000100002.View ArticlePubMedGoogle Scholar
- Bang AT, Reddy HM, Deshmukh MD, Baitule SB, Bang RA: Neonatal and infant mortality in the ten years (1993 to 2003) of the Gadchiroli field trial: effect of home-based neonatal care. J Perinatol. 2005, 25: S92-107. 10.1038/sj.jp.7211277.View ArticlePubMedGoogle Scholar
- Tripathy P, Nair N, Barnett S, Mahapatra R, Borghi J, Rath S, et al: Effect of a participatory intervention with women's groups on birth outcomes and maternal depression in Jharkhand and Orissa, India: a cluster-randomised controlled trial. Lancet. 2010, 375: 1182-92. 10.1016/S0140-6736(09)62042-0.View ArticlePubMedGoogle Scholar
- Azad K, Barnett S, Banerjee B, Shaha S, Khan K, Rego AR, et al: Effect of scaling up women's groups on birth outcomes in three rural districts in Bangladesh: a cluster-randomised controlled trial. Lancet. 2010, 375: 1193-202. 10.1016/S0140-6736(10)60142-0.View ArticlePubMedGoogle Scholar
- Manandhar DS, Osrin D, Shrestha B, et al: Effect of a participatory intervention with women's groups on birth outcomes in Nepal: cluster-randomised controlled trial. Lancet. 2004, 364: 970-79. 10.1016/S0140-6736(04)17021-9.View ArticlePubMedGoogle Scholar
- Howard-Grabman L, Snetro G: How to mobilise communities for health and social change. 2003, Baltimore, MD: Health Communication Partnership/USAIDGoogle Scholar
- Borghi J, Thapa B, Osrin D, Jan S, Morrison J, Tamang S, et al: Economic assessment of a women's group intervention to improve birth outcomes in rural Nepal. Lancet. 2005, 1882-4. 10.1016/S0140-6736(05)67758-6.Google Scholar
- Anonymous: MotherCare/Bolivia. MotherCare Matters. 1999, 8: 8-16. [MotherCare website on-line.] Cited May 31, 2006, [http://www.mothercare.jsi.com/pubs/mcmatters/pdf/Vol8-2.pdf]Google Scholar
- Marsh DR, Schroeder DG, Dearden KA, Sternin J, Sternin M: The power of positive deviance. BMJ. 2004, 329: 1177-9. 10.1136/bmj.329.7475.1177.View ArticlePubMedPubMed CentralGoogle Scholar
- Berggren WL, Wray JD: Positive deviant behavior and nutrition education. Food Nutr Bull. 2002, 23: 9-10.View ArticlePubMedGoogle Scholar
- Fullerton JT, Killian R, Gass PM: Outcomes of a community and home-based intervention for safe motherhood and newborn care. Health Care Women Int. 26: 561-576. 10.1080/07399330591004881.
- Ensor T, Cooper S: Overcoming barriers to health service access: influencing the demand side. Health Policy Plan. 2004, 19: 69-79. 10.1093/heapol/czh009.View ArticlePubMedGoogle Scholar
- Stanton CK: Methodological issues in the measurement of birth preparedness in support of safe motherhood. Eval Rev. 2004, 28: 179-200. 10.1177/0193841X03262577.View ArticlePubMedGoogle Scholar
- McPherson RA, Khadka N, Moore JM, Sharma M: Are birth-preparedness programmes effective? Results from a field trial in Siraha district, Nepal. J Health Popul Nutr. 2006, 24: 479-88.PubMedPubMed CentralGoogle Scholar
- Sibley LM, Sipe TA: Transition to skilled birth attendance: Is there a future role for trained traditional birth attendants?. J Health Popul Nutr. 2006, 24: 472-8.PubMedPubMed CentralGoogle Scholar
- Sibley L, Sipe TA, Koblinsky M: Does traditional birth attendant training improve referral of women with obstetric complications: a review of the evidence. Soc Sci Med. 2004, 59: 1757-68. 10.1016/j.socscimed.2004.02.009.View ArticlePubMedGoogle Scholar
- Sibley LM, Sipe TA, Brown CM, Diallo MM, McNatt K, Habarta N: Traditional birth attendant training for improving health behaviours and pregnancy outcomes. Cochrane Database of Systematic Reviews. 2007, CD005460-3
- Hofmeyr GJ, Haws RA, Bergström S, Lee AC, Okong P, Darmstadt GL, Mullany LC, Oo EK, Lawn JE: Obstetric care in low-resource settings: what, who, and how to overcome challenges to scale up?. Int J Gynaecol Obstet. 2009, 107 (Suppl 1): S21-44. 10.1016/j.ijgo.2009.07.017. S44-5View ArticlePubMedGoogle Scholar
- Darmstadt GL, Bhutta ZA, Cousens S, Adam T, Walker N, de Bernis L: Lancet Neonatal Survival Steering Team. Evidence-based, cost-effective interventions: how many newborn babies can we save?. Lancet. 2005, 365: 977-988. 10.1016/S0140-6736(05)71088-6.View ArticlePubMedGoogle Scholar
- Draycott T, Sibanda T, Owen L, Akande V, Winter C, Reading S, Whitelaw A: Does training in obstetric emergencies improve neonatal outcome?. BJOG. 2006, 113: 177-82. 10.1111/j.1471-0528.2006.00800.x.View ArticlePubMedGoogle Scholar
- Sloan NL, Nguyen TN, Do TH, Quimby C, Winikoff B, Fassihian G: Effectiveness of lifesaving skills training and improving institutional emergency obstetric care readiness in Lam Dong, Vietnam. J Midwif Womens Health. 2005, 50: 315-23. 10.1016/j.jmwh.2004.08.018.View ArticleGoogle Scholar
- Pattinson R, Kerber K, Waiswa P, Day LT, Mussell F, Asiruddin SK, Blencowe H, Lawn JE: Perinatal mortality audit: counting, accountability, and overcoming challenges in scaling up in low- and middle-income countries. Int J Gyn Obstet. 2009, 107: S113-21. 10.1016/j.ijgo.2009.07.011.View ArticleGoogle Scholar
- Carlo WA, Goudar SS, Jehan I, Chomba E, Tshefu A, Garces A, Parida S, et al: FIRST BREATH Trial. Newborn-care training and perinatal mortality in developing countries. N Engl J Med. 2010, 362: 614-23. 10.1056/NEJMsa0806033.View ArticlePubMedPubMed CentralGoogle Scholar
- Buffington S, Sibley L, Beck D, Armbruster D: Home Based Life Saving Skills. 2004, Washington (DC): American College of Nurse Midwives, 1Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/10/82/prepub
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